您好，欢迎访问天津市农业科学院 机构知识库！
天津市农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Identification of genes related to resistance against S. Typhimurium in ovine macrophages

文献类型： 外文期刊

作者： Wang, Mengyao 1 ; Yang, Dongbing 1 ; Liu, Zhexi 1 ; Wei, Shao 1 ; Wang, Linli 1 ; Ai, Yue 1 ; Zhang, Xiaosheng 4 ; Han, H 1 ;

作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, Beijing Key Lab Anim Genet Improvement, Beijing, Peoples R China

2.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Beijing, Peoples R China

3.China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, Minist Agr & Rural Affairs, Beijing, Peoples R China

4.Tianjin Acad Agr Sci, Inst Anim Sci & Vet Med, Tianjin, Peoples R China

关键词： Sheep; Macrophage; S. Typhimurium; RNA-seq

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2020 年 139 卷

页码：

收录情况： SCI

摘要： Salmonella enteric serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen causing public health hazards. Identification of genes related to macrophages resistance to S. Typhimurium and their immune mechanisms can provide a theoretical basis for disease resistance. In this study, sixty significant differentially expressed genes were screened between susceptible and resistant sheep macrophages by transcriptome RNA-seq. Eight significantly enriched GO terms and six canonical pathways were involved by GO and KEGG enrichment analysis. Furthermore, knockdown of HMOX1 and SLPI increased remarkably the clearance of S. typhimurium, but SPP1 had little effect on the clearance of S. Typhimurium within sheep macrophages. Altogether, these results suggest that many genes of macrophages were reprogrammed via S. Typhimurium infection, some of which may facilitate host defence against Salmonella, while others allow Salmonella to escape.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：天津市农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台