Progranulin suppresses the age-dependent enhancement of neuronal activity in the hypothalamus
文献类型： 外文期刊
作者： Bai, Dongying 1 ; Ma, Yihong 2 ; Lv, Leyuan 1 ; Wang, Yun 3 ; Yang, Wanqing 4 ; Ma, Yanbo 1 ;
作者机构： 1.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Dept Anim Physiol, Luoyang 471003, Peoples R China
2.Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Kumamoto 8600811, Japan
3.Chinese Acad Fishery Sci, South China Pearl River Fisheries Res Inst, Minist Agr, Key Lab Aquat Prod Proc, Guangzhou 510300, Peoples R China
4.Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Physiol, Tokyo 1138657, Japan
关键词： Progranulin; Lysosome; Aging; Neuronal activity; Microglia
期刊名称：NEUROSCIENCE LETTERS （ 影响因子：3.046； 五年影响因子：2.855 ）
ISSN： 0304-3940
年卷期： 2020 年 720 卷
页码：
收录情况： SCI
摘要： Our previous investigations revealed that progranulin (PGRN) is a lysosomal protein involved in hippocampal neurogenesis and neuroinflammation. However, the possible involvement of PGRN in regulating inflammatory response and mediating neuronal activity is still not well-defined. Here, we demonstrate that PGRN deficiency enhances the age-dependent increase of neuronal activity in the paraventricular nucleus (PVN) of the hypothalamus. Aging increased neuronal activity in the PVN of the hypothalamus, and PGRN deficiency enhanced the effects of age on hypothalamic neuronal activity. Aging increased the lysosomal biogenesis and inflammatory response in microglia, which was also aggravated in PGRN-knockout mice. Moreover, PGRN deficiency enhanced interleukin-1 beta and lysosomal genes levels. These results suggest that PGRN deficiency may enhance the age-dependent increase of neuronal activity possibly because PGRN facilitates immunological responses through regulating lysosomal function.
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