Quantitative determination of rifampicin in aquatic products by stable isotope-dilution high liquid chromatography-tandem mass spectrometry
文献类型： 外文期刊
作者： Li, Qin 1 ; Cao, Jingyuan 4 ; Han, Gang 1 ; Liu, Huan 1 ; Yan, Jie 1 ; Wu, Lidong 1 ; Li, Jincheng 1 ;
作者机构： 1.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shangha, Peoples R China
2.Chinese Acad Fishery Sci, Beijing 100141, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Control Qual & Safety Aquat Prod, Beijing, Peoples R China
4.Beijing Univ Agr, Beijing, Peoples R China
关键词： aquatic products; determination; high liquid chromatography-tandem mass spectrometry; rifampin
期刊名称：BIOMEDICAL CHROMATOGRAPHY （ 影响因子：1.902； 五年影响因子：1.809 ）
ISSN： 0269-3879
年卷期：
页码：
收录情况： SCI
摘要： Rifampicin is a semi-synthetic broad-spectrum antibiotic obtained from rifamycin B. It is one of the most effective first-line antituberculosis drugs and is widely used in clinical practice. In the present study, we describe a rapid and sensitive method for the determination of rifampin in aquatic products by stable isotope-dilution high liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Samples were extracted with the acetonitrile, degreased by hexane, and then concentrated by nitrogen blowing. After separation using a C-18 column with a mixture of acetonitrile and water as mobile phase, it was determined by HPLC-MS/MS using the stable isotope-dilution calibration method. The performance of our method was validated. The limit of detection was 0.25 mu g kg(-1) and the limit of quantification was 0.5 mu g kg(-1). At the three spiked levels of 0.5, 1.0 and 5.0 mu g kg(-1), the average recoveries of rifampicin in different aquatic products were between 75.28 and 107.6%, and the relative standard deviation ranged from 0.81 to 13.23%. This method was successfully applied for the determination of rifampin in different kinds of aquatic products and rifampicin residue was found in aquatic products obtained from markets in Beijing, China.
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