The RNA-Dependent RNA Polymerase NIb of Potyviruses Plays Multifunctional, Contrasting Roles during Viral Infection
文献类型： 外文期刊
作者： Shen, Wentao 1 ; Shi, Yan 3 ; Dai, Zhaoji 4 ; Wang, Aiming 4 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
3.Henan Agr Univ, Coll Plant Protect, Zhengzhou 450002, Peoples R China
4.Agr & Agri Food Canada, London Res & Dev Ctr, 1391 Sandford ST, London, ON N5V 4T3, Canada
5.Univ Western Ontario, Dept Biol, 1151 Richmond ST N, London, ON N6A 5B7, Canada
关键词： Potyvirus; NIb; RNA-dependent RNA polymerase; virus-host interaction; autophagy; sumoylation; NPR1
期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）
ISSN：
年卷期： 2020 年 12 卷 1 期
页码：
收录情况： SCI
摘要： Potyviruses represent the largest group of known plant RNA viruses and include many agriculturally important viruses, such as Plum pox virus, Soybean mosaic virus, Turnip mosaic virus, and Potato virus Y. Potyviruses adopt polyprotein processing as their genome expression strategy. Among the 11 known viral proteins, the nuclear inclusion protein b (NIb) is the RNA-dependent RNA polymerase responsible for viral genome replication. Beyond its principal role as an RNA replicase, NIb has been shown to play key roles in diverse virus-host interactions. NIb recruits several host proteins into the viral replication complexes (VRCs), which are essential for the formation of functional VRCs for virus multiplication, and interacts with the sumoylation pathway proteins to suppress NPR1-mediated immunity response. On the other hand, NIb serves as a target of selective autophagy as well as an elicitor of effector-triggered immunity, resulting in attenuated virus infection. These contrasting roles of NIb provide an excellent example of the complex co-evolutionary arms race between plant hosts and potyviruses. This review highlights the current knowledge about the multifunctional roles of NIb in potyvirus infection, and discusses future research directions.
- 相关文献
作者其他论文 更多>>
-
A telosma mosaic virus-based vector for foreign gene expression and virus-induced gene silencing in passion fruit
作者：Wang, Xiaoqing;Qin, Li;Cui, Hongguang;Dai, Zhaoji;Shen, Wentao;Shen, Wentao;Qiu, Wenping
关键词：
-
A Comprehensive Screening of the Interactors of Areca Palm Necrotic Ringspot Virus (ANRSV) HCPro2 Highlights the Proviral Roles of eIF4A and PGK in Viral Infection
作者：Qin, Li;Liu, Peilan;Dai, Zhaoji;Cui, Hongguang;Shen, Wentao
关键词：
Potyviridae ; leader protease; cysteine protease; eukaryotic initiation factor 4A; phosphoglycerate kinase -
Pearl Bodies as a Potential Source of Secondary Transmission of Papaya Leaf Distortion Mosaic Virus in Carica papaya
作者：Tuo, Decai;Su, Die;Yan, Pu;Xue, Weiqian;Xie, Zhengnan;Zhou, Peng;Kong, Hua;Shen, Wentao;Tuo, Decai;Su, Die;Yan, Pu;Xue, Weiqian;Xie, Zhengnan;Zhou, Peng;Kong, Hua;Shen, Wentao;Su, Die;Xue, Weiqian;Zhao, Mengwei
关键词：infection; papaya leaf distortion mosaic virus; pearl bodies; transmission
-
Natural self-attenuation of pathogenic viruses by deleting the silencing suppressor coding sequence for long-term plant-virus coexistence
作者：Qin, Li;Wang, Xiaoqing;Dai, Zhaoji;Cui, Hongguang;Shen, Wentao;Shen, Wentao;Li, Fangfang;Wang, Aiming;Valli, Adrian A.
关键词：
-
A Point Mutation in the Pepper Veinal Mottle Virus 6K1 Protein Yields a Stable Attenuated Strain for Engineering Virus Resistance in Pepper Plants
作者：Deng, Changhui;Hu, Weiyao;Dai, Zhaoji;Cui, Hongguang;Deng, Changhui;Hu, Weiyao;Dai, Zhaoji;Cui, Hongguang;Shen, Wentao;Li, Fangfang
关键词：cross protection; pathogen-derived resistance; pepper veinal mottle virus; viral vector; virus resistance
-
Rubisco small subunit (RbCS) is co-opted by potyvirids as the scaffold protein in assembling a complex for viral intercellular movement
作者：Qin, Li;Liu, Hongjun;Liu, Peilan;Jiang, Lu;Dai, Zhaoji;Cui, Hongguang;Qin, Li;Liu, Hongjun;Liu, Peilan;Jiang, Lu;Dai, Zhaoji;Cui, Hongguang;Jiang, Lu;Li, Fangfang;Cheng, Xiaofei;Shen, Wentao;Qiu, Wenping
关键词：
-
Mutating the arginine residue within the FRNK motif of telosma mosaic virus (TelMV) HC-Pro protein attenuates viral infection and confers effective protection against TelMV in passion fruit (Passiflora edulis)
作者：Wang, Linxi;Shi, Wei;Aziz, Asma;Wang, Xiaoqing;Liu, Haobin;Cui, Hongguang;Dai, Zhaoji;Shen, Wentao
关键词：telosma mosaic virus; cross protection; HC-Pro; FRNK; passion fruit; attenuated mutant
