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Mimicking neuromelanin nanoparticles as a selective Pb2+ probe

文献类型： 外文期刊

作者： Zhang, Shu 1 ; Xiao, Ming 3 ; Zhang, Yuqian 4 ; Li, Yang 4 ; Liu, Huan 2 ; Han, Gang 2 ; Rathi, Brijesh 5 ; Lyu, Kaiyu 1 ; W 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Agr Econ & Dev, Beijing 100081, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab Control Qual & Safety Aquat Prod, Minist Agr, Beijing 100141, Peoples R China

3.Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Lab Immunol & Nanomed,Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China

5.Univ Delhi, Hansraj Coll, Dept Chem, Lab Translat Chem & Drug Discovery, Delhi 110007, India

关键词： Neuromelanin-like nanoparticles; Amino acid; Fluorescence; Lead ions

期刊名称：ANALYTICA CHIMICA ACTA （ 影响因子：6.558； 五年影响因子：6.228 ）

ISSN： 0003-2670

年卷期： 2020 年 1105 卷

页码：

收录情况： SCI

摘要： Exposure to even very low concentration of Pb2+ can cause neurological and developmental disorders, and affects children more severely. Neuromelanin (NM) in the substantial nigra can trap endogenous and environmental toxins and immobilize them as stable adducts, thus protecting brain against toxicity. Until now, the structure and Pb2+-chelating ability of NM is still little understood. Here, we prepare a mimicking NM by amino acid and dopamine. The prepared NM has strong fluorescent and its fluorescence can be quenched by Pb2+. This study offers a novel way to synthetic NM and provides an effective method to detect Pb2+. (C) 2020 Elsevier B.V. All rights reserved.

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