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Gold nanoparticles enhance immune responses in mice against recombinant classical swine fever virus E2 protein

文献类型： 外文期刊

作者： Li, Yafei 1 ; Jin, Qianyue 1 ; Ding, Peiyang 4 ; Zhou, Wen 1 ; Chai, Yongxiao 1 ; Li, Xufeng 1 ; Wang, Yao 1 ; Zhang, Gai 1 ;

作者机构： 1.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

2.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

3.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

4.Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Peoples R China

5.Henan Agr Univ, Coll Anim Husb & Vet Sci, Zhengzhou 450002, Peoples R China

关键词： Gold nanoparticles; Classical swine fever virus; E2 protein; Carrier; Subunit vaccine

期刊名称：BIOTECHNOLOGY LETTERS （ 影响因子：2.461； 五年影响因子：2.457 ）

ISSN： 0141-5492

年卷期：

页码：

收录情况： SCI

摘要： Objective To create a novel subunit vaccine that used AuNPs as carriers to enhance immune responses in mice against recombinant classical swine fever virus E2 protein (CSFV E2). Results Gold nanoparticles (AuNPs) were successfully coupled to the E2 protein and formed stable particle complexes called E2 conjugated AuNPs (E2-AuNPs). In vitro studies have shown that the E2-AuNPs complex has the same immunogenicity as the E2 protein, and AuNPs can promote the phagocytosis of the E2 protein by antigen-presenting cells (APCs). In vivo results of BALB/c mice showed that the antibody levels, lymphocyte proliferation index, IFN-gamma and IL-10 cytokines induced by E2-AuNPs were relatively higher than those of E2 or AuNPs group. Conclusions This finding demonstrated the potential of using AuNPs as a carrier to enhance the body's immune response for developing CSFV subunit vaccines. This model also contributes to the development of other flavivirus subunit vaccines, such as hepatitis C virus (HCV) and bovine viral diarrhea virus (BVDV).

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