Theaflavin TF3 Relieves Hepatocyte Lipid Deposition through Activating an AMPK Signaling Pathway by targeting Plasma Kallikrein
文献类型： 外文期刊
作者： Zhang, Wenji 3 ; An, Ran 1 ; Li, Qiuhua 3 ; Sun, Lingli 3 ; Lai, Xingfei 3 ; Chen, Ruohong 3 ; Li, Dongli 1 ; Sun, Shili 3 ;
作者机构： 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
2.Int Healthcare Innovat Inst Jiangmen, Jiangmen 529040, Peoples R China
3.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Key Lab Tea Resources Innovat & Utiliza, Guangzhou 510640, Peoples R China
关键词： hepatocyte lipid deposition; nonalcoholic fatty liver disease; black tea; theaflavin-3,3 '-digallate; plasma kallikrein; AMPK kinase
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）
ISSN： 0021-8561
年卷期： 2020 年 68 卷 9 期
页码：
收录情况： SCI
摘要： Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the leading cause of chronic liver diseases throughout the world. The deficit of pharmacotherapy for NAFLD calls for an urgent need for a new drug discovery and lifestyle management. Black tea is the most popular and functional drink consumed worldwide. Its main bioactive constituent theaflavin helps to prevent obesity-a major risk factor for NAFLD. To find new targets for the development of effective and safe therapeutic drugs from natural plants for NAFLD, we found a theaflavin monomer theaflavin-3,3'-digallate (TF3), which significantly reduced lipid droplet accumulation in hepatocytes, and directly bound and inhibited the activation of plasma kallikrein (PK), which was further proved to stimulate adenosine monophosphate activated protein kinase (AMPK) and its downstream targets. Taken together, we proposed that the TF3-PK-AMPK regulatory axis is a novel mechanism of lipid deposition mitigation, and PK could be a new target for NAFLD treatment.
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