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Dynamics of cardiomyocyte and muscle stem cell proliferation in pig

文献类型： 外文期刊

作者： Yin, Binxu 1 ; Ren, Hongyan 2 ; Cai, Hao 1 ; Jiang, Yunqi 1 ; Zhao, Shuhong 1 ; Wang, Heng 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China

2.Hubei Acad Agr Sci, Inst Vet & Anim Sci, Key Lab Anim Embryo & Mol Breeding Hubei Prov, Wuhan 430064, Peoples R China

关键词： Cell proliferation; Cardiomyocyte; Muscle stem cell; Pig

期刊名称：EXPERIMENTAL CELL RESEARCH （ 影响因子：3.905； 五年影响因子：4.121 ）

ISSN： 0014-4827

年卷期： 2020 年 388 卷 2 期

页码：

收录情况： SCI

摘要： The cardiac and skeletal muscle tissues are both striated and contractile but their intrinsic cellular properties are distinct. The minimal cardiomyocyte proliferation and the lack of cardiac stem cells directly leads to poor heart repair in adult mammals. But in skeletal muscle, the robust proliferation of widespread muscle stem cells support efficient muscle regeneration. The endogenous cardiomyocyte and muscle stem cell proliferation has been analyzed in common laboratory animals but not in large mammals including pigs, which are more comparable to human. In this study, we rigorously examined the cell cycle dynamics of porcine cardiomyocytes and muscle stem cells through different developmental stages. Proliferative cardiomyocytes and muscle stem cells were broadly observed in the embryonic heart and limb muscle respectively. Muscle stem cells continue to proliferate postnatally but cardiomyocyte proliferation was drastically reduced after birth. However, robust cardiomyocyte cell cycle activity was detected around postnatal day 20, which could be attributed to the binucleation but not cell division. Increased proliferating cells were detected in maternal heart during early pregnancy but they represent non-cardiomyocyte cell types. The islet1 expressing cells were only identified in the embryonic and new born porcine hearts. Furthermore, the accumulated oxidative DNA damage in the cardiac but not skeletal muscle during development could be responsible for the diminished cardiomyocyte proliferation in adult pig. Similarities and differences in the proliferation of heart and skeletal muscle cells are identified in pigs across different developmental stages. Such cellular proliferative features must be taken into account when using porcine models for cardiovascular and muscular research.

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