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MHC-DRB1 exon 2 polymorphism and its association with mycoplasma ovipneumonia resistance or susceptibility genotypes in sheep

文献类型： 外文期刊

作者： Wang, Kaisheng 1 ; Liu, Xianxia 1 ; Li, Qiongqiong 2 ; Wan, Kexing 2 ; Gao, Rui 2 ; Han, Guohua 1 ; Li, Chaochen 1 ; Xu, 1 ;

作者机构： 1.Shihezi Univ, Coll Anim Sci & Technol, Shihezi 832000, Xinjiang, Peoples R China

2.Shihezi Univ, Sch Med, Shihezi 832000, Xinjiang, Peoples R China

3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Xinjiang, Peoples R China

4.Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621000, Sichuan, Peoples R China

5.Guizhou Normal Univ, Sch Karst Sci, State Engn Technol Inst Karst Desertificat Contro, Guiyang 550000, Guizhou, Peoples R China

6.Yulin Normal Univ, Coll Biol & Pharm, Yulin 537000, Guangxi, Peoples R China

关键词： polymorphism; genotypes; mycoplasma pneumonia; immune factors; resistance; susceptibility

期刊名称：JOURNAL OF GENETICS （ 影响因子：1.166； 五年影响因子：1.212 ）

ISSN： 0022-1333

年卷期： 2020 年 99 卷 1 期

页码：

收录情况： SCI

摘要： Major histocompatibility complex (MHC) polymorphisms are associated with animal and human diseases. However, only a few studies have reported an association between MHC polymorphisms and mycoplasma ovipneumonia (MO). In the present study, three resistance/susceptibility genotypes associated with MO were identified by polymerase chain reaction-restriction fragment length polymorphism genotyping, assessing the clinical and pathological features, and examining the immune factors. The current results showed that MvaI bb and HaeIII ee were dominant genotypes in the susceptible Hu population, while MO-resistant populations, Dorper and D x H hybrids, were dominated by the MvaI cc and HaeIII dd genotypes, suggesting that MvaI cc and HaeIII dd genotypes might be associated with the trait of MO resistance. Further, the clinical symptoms and pathological morphology in the susceptibility group infected with MO were more severe than those in the resistant groups infected similarly. The data on the changes in the immune factor responses were utilized to deduce the molecular mechanism underlying the MO resistance/susceptibility. The results showed that the susceptible genotypes promote the inflammatory responses by inducing a high expression of TNF alpha, IFN gamma, IL-4, IL-6, and IL-1 beta, while the resistant genotypes inhibit the inflammatory response by increasing the expression of IL-2 and IL-10 significantly. This finding would provide the theoretical guidance for propagating sheep breeds that are highly resistant to MO.

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