Characterization of the First Genome of Porcine mastadenovirus B (HNU1 Strain) and Implications on Its Lymphoid and Special Origin
文献类型： 外文期刊
作者： Liu, Shu-Jing 1 ; Wang, Qiong 1 ; Li, Ting-Ting 2 ; Zhang, Si-Hua 3 ; Li, Jin-Yan 1 ; Wu, Li-Jun 4 ; Qiu, Ye 1 ; Ge, Xing 1 ;
作者机构： 1.Hunan Univ, Coll Biol, Inst Pathogen Biol & Immunol, Hunan Prov Key Lab Med Virol, Changsha 410082, Hunan, Peoples R China
2.Hubei Anim Dis Prevent & Control Ctr, Wuhan 430070, Peoples R China
3.Wuhan Anim Dis Prevent & Control Ctr, Wuhan 430016, Peoples R China
4.Wuhan Acad Agr Sci, Wuhan 430065, Peoples R China
关键词： Porcine adenovirus (PAdV); PAdV-B; PAdV-B-HNU1; Lymphoid
期刊名称：VIROLOGICA SINICA （ 影响因子：4.327； 五年影响因子：4.08 ）
ISSN： 1674-0769
年卷期：
页码：
收录情况： SCI
摘要： Porcine adenoviruses (PAdVs) are classified into three species, PAdV-A, PAdV-B, and PAdV-C. The genomes of PAdV-A and PAdV-C have been well characterized. However, the genome of PAdV-B has never been completely sequenced, and the epidemiology of PAdV-B remains unclear. In our study, we have identified a novel strain of PAdV-B, named PAdV-B-HNU1, in porcine samples collected in China by viral metagenomic assay and general PCR. The genome of PAdV-B-HNU1 is 31,743 bp in length and highly similar to that of California sea lion adenovirus 1 (C. sea lion AdV-1), which contains typical mastadenoviral structures and some unique regions at the carboxy-terminal end. Especially, PAdV-B-HNU1 harbors a dUTPase coding region not clustering with other mastadenoviruses except for C. sea lion AdV-1 and a fiber coding region homologous with galectin 4 and 9 of animals. However, the variance of GC contents between PAdV-B-HNU1 (55%) and C. sea lion AdV-1 (36%) indicates their differential evolutionary paths. Further epidemiologic study revealed a high positive rate (51.7%) of PAdV-B-HNU1 in porcine lymph samples, but low positive rates of 10.2% and 16.1% in oral swabs and rectal swabs, respectively. In conclusion, this study characterized a novel representative genome of a lymphotropic PAdV-B with unique evolutionary origin, which contributes to the taxonomical and pathogenic studies of PAdVs.
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