A strategy for construction of highly sensitive glycosyl imprinted electrochemical sensor based on sandwich-like multiple signal enhancement and determination of neural cell adhesion molecule
文献类型： 外文期刊
作者： Ma, Xionghui 1 ; Li, Mengxi 2 ; Tong, Peihong 1 ; Zhao, Chengjun 1 ; Li, Jianping 1 ; Xu, Guobao 4 ;
作者机构： 1.Guilin Univ Technol, Coll Chem & Bioengn, Guilin 541004, Peoples R China
2.Univ Edinburgh, Sch Biol Sci, Inst Quantitat Biol Biochem & Biotechnol, Edinburgh EH9 3JQ, Midlothian, Scotland
3.Chinese Acad Trop Agr Sci, Anal & Test Ctr, Haikou 571101, Hainan, Peoples R China
4.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
关键词： Glycosyl imprinting; Electrochemical sensor; Multiple signal enhancement; Neural cell adhesion molecule; Boric acid affinity; Macromolecules
期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.618； 五年影响因子：9.323 ）
ISSN： 0956-5663
年卷期： 2020 年 156 卷
页码：
收录情况： SCI
摘要： A novel electrochemical sensor for a neural cell adhesion molecule (CD56) was constructed by glycosyl imprinting. A sandwich-like multi-signal generation strategy was first proposed in glycosyl imprinting sensors via boric acid affinity. Glycosyl-imprinted polymers were formed by electro-polymerization with poly-sialic acid (PolySia) as a template molecule and p-aminobenzeneboronic (p-ABA) acid as a functional monomer. Methods such as scanning electron microscope (SEM), Fourier transform infrared spectrum (FT-IR), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) were used to characterize the successful formation of imprinted membranes. Confirmed by both simulation calculation and experimental results, a signal-amplified effect based on macromolecules was introduced for the first time. After re-absorption, aminobenzene borate was linked to the surface of the sensor by boric acid affinity due to the rich hexadoxyl structure of the CD56-terminal chain as a signal probe. Under optimal conditions, the detection limit of the sensor is as low as 0.47 ng/L, and it can be successfully applied to the detection of CD56 in human serum.
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