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A strategy for construction of highly sensitive glycosyl imprinted electrochemical sensor based on sandwich-like multiple signal enhancement and determination of neural cell adhesion molecule

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文献类型：外文期刊

作者： Ma, Xionghui ¹ ; Li, Mengxi ² ; Tong, Peihong ¹ ; Zhao, Chengjun ¹ ; Li, Jianping ¹ ; Xu, Guobao ⁴ ;

作者机构： 1.Guilin Univ Technol, Coll Chem & Bioengn, Guilin 541004, Peoples R China

2.Univ Edinburgh, Sch Biol Sci, Inst Quantitat Biol Biochem & Biotechnol, Edinburgh EH9 3JQ, Midlothian, Scotland

3.Chinese Acad Trop Agr Sci, Anal & Test Ctr, Haikou 571101, Hainan, Peoples R China

4.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China

关键词： Glycosyl imprinting; Electrochemical sensor; Multiple signal enhancement; Neural cell adhesion molecule; Boric acid affinity; Macromolecules

期刊名称：BIOSENSORS & BIOELECTRONICS （影响因子：10.618；五年影响因子：9.323 ）

ISSN： 0956-5663

年卷期： 2020 年 156 卷

页码：

收录情况： SCI

摘要： A novel electrochemical sensor for a neural cell adhesion molecule (CD56) was constructed by glycosyl imprinting. A sandwich-like multi-signal generation strategy was first proposed in glycosyl imprinting sensors via boric acid affinity. Glycosyl-imprinted polymers were formed by electro-polymerization with poly-sialic acid (PolySia) as a template molecule and p-aminobenzeneboronic (p-ABA) acid as a functional monomer. Methods such as scanning electron microscope (SEM), Fourier transform infrared spectrum (FT-IR), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) were used to characterize the successful formation of imprinted membranes. Confirmed by both simulation calculation and experimental results, a signal-amplified effect based on macromolecules was introduced for the first time. After re-absorption, aminobenzene borate was linked to the surface of the sensor by boric acid affinity due to the rich hexadoxyl structure of the CD56-terminal chain as a signal probe. Under optimal conditions, the detection limit of the sensor is as low as 0.47 ng/L, and it can be successfully applied to the detection of CD56 in human serum.

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