Design, synthesis, and evaluation of novel arecoline-linked amino acid derivatives for insecticidal and antifungal activities
文献类型： 外文期刊
作者： Pang, Chaohai 1 ; Xu, Yuan 2 ; Ma, Xionghui 1 ; Li, Shuhuai 1 ; Zhou, Shengfu 3 ; Tian, Hai 1 ; Wang, Mingyue 1 ; Han, Bingjun 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Anal & Test Ctr, Hainan Prov Key Lab Qual & Safety Trop Fruits & Ve, Minist Agr & Rural Affairs,Key Lab Qual & Safety C, Haikou 571101, Peoples R China
2.Hainan Med Univ, Engn Res Ctr Trop Med Innovat & Transformat, Int Joint Res Ctr Human machine Intelligent Collab, Minist Educ,Sch Pharm,Hainan prov key lab Res & de, Haikou 571199, Peoples R China
3.BayRay Innovat Ctr, Shenzhen Bay Lab, Shenzhen 518000, Peoples R China
关键词： Arecoline; Derivatives; Insecticidal activity; Fungicidal activity; Molecular docking
期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.6； 五年影响因子：4.9 ）
ISSN： 2045-2322
年卷期： 2024 年 14 卷 1 期
页码：
收录情况： SCI
摘要： A series of arecoline derivatives with amino acid moieties were designed and synthesised using an acylamide condensation strategy, taking arecoline as the foundational structure. The insecticidal efficacy of these compounds against Aphis craccivora and Tetranychus cinnabarinus was evaluated. Notably, derivatives 3h and 3i demonstrated superior insecticidal activity compared with arecoline. Additionally, 3h and 3i showed good fungicidal effectiveness against two types of plant fungi. Moreover, molecular docking analyses suggested that 3h and 3i could affect the nervous systems of A. craccivora and T. cinnabarinus by binding to neuronal nicotinic acetylcholine receptors. These findings suggest that compounds 3h and 3i represent promising leads for further development in insecticide and fungicide research.
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