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Jasmine (Jasminurn grandiflorum) Flower Extracts Ameliorate Tetradecanoylphorbol Acetate Induced Ear Edema in Mice

文献类型： 外文期刊

作者： Li, Dongli 1 ; Tang, Xiaodan 1 ; Liu, Chang 3 ; Li, Huifang 1 ; Li, Shuzhen 1 ; Sun, Shili 4 ; Zheng, Xi 1 ; Wu, Panpan 1 ;

作者机构： 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, 22 Dongcheng Village, Jiangmen 529020, Peoples R China

2.Int Healthcare Innovat Inst Jiangmen, Jiangmen, Peoples R China

3.Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA

4.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innova, Guangzhou, Peoples R China

关键词： jasmine flower; Jasminum grandiflorum; phenolics; oleuropein; tetradecanoylphorbol acetate (TPA); anti-inflammation

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

ISSN： 1934-578X

年卷期： 2020 年 15 卷 4 期

页码：

收录情况： SCI

摘要： Published data from in vitro assays support the anti-inflammatory effects of jasmine (Jasminum grandiflorum Linn.) but limited studies are reported in animal models. Herein, the anti-inflammatory effects of jasmine flower extracts OFEs) including ethanol extract OF-EE), petroleum ether extract OF-PEE), ethyl acetate extract UF-EAE), and n-butanol extract OF-BE) were evaluated in a mouse ear edema model. Acute mouse ear skin inflammation was induced by tetradecanoylphorbol acetate (TPA; 125 mu g/mL) and then treated with JFEs (100 mg/mL) or dexamethasone (DEX; 6.25 mg/mL; as a positive control). Jasmine flower extracts alleviated ear edema by reducing TPA-increased ear thickness and ear weight by 30.8% to 64.1% and 24.0% to 47.1%, respectively, whereas DEX showed comparable activity (by 71.8% and 49.1%, respectively). Their anti-inflammatory effects were supported by data from the immunohistochemical assays. Jasmine flower extracts reduced the inflammatory cells (from 5.5- to 9.5-fold) and the expressions of inflammation related enzymes including cyclooxygenase-2 and inhibitor of kappa-B kinase (from 1.9- to 2.8-fold and from 7.1- to 11.0-fold, respectively). Findings from this study showed that JFEs were able to ameliorate TPA-induced mouse skin inflammation. However, future studies on the underlying mechanisms of jasmine flower's anti-inflammatory effects are warranted.

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