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Structural Features of Three Hetero-Galacturonans from Passiflora foetida Fruits and Their In Vitro Immunomodulatory Effects

文献类型： 外文期刊

作者： Song, Ya 1 ; Wen, Peng 1 ; Hao, Huili 1 ; Zhu, Minqian 1 ; Sun, Yuanming 1 ; Zou, Yuxiao 2 ; Requena, Teresa 5 ; Huang, R 1 ;

作者机构： 1.South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Food Qual & Safety, Guangzhou 510642, Peoples R China

2.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou 510610, Peoples R China

3.Minist Agr, Key Lab Funct Foods, Guangzhou 510610, Peoples R China

4.Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Peoples R China

5.Univ Autonoma Madrid, Inst Invest Ciencias Alimentac CIAL CSIC UAM, Nicolas Cabrera 9,Campus Cantoblanco, E-28049 Madrid, Spain

关键词： structural features; immunomodulatory effect; Passiflora foetida fruits; hetero-galacturonans

期刊名称：POLYMERS （ 影响因子：4.329； 五年影响因子：4.493 ）

ISSN：

年卷期： 2020 年 12 卷 3 期

页码：

收录情况： SCI

摘要： Passiflora foetida is a horticultural plant and vital traditional Chinese herbal medicine. In our previous study, the characterization and immuno-enhancing effect of fruits polysaccharide 1 (PFP1), a water-eluted hetero-mannan from wild Passiflora foetida fruits, were investigated. Herein, another three salt-eluted novel polysaccharides, namely PFP2, PFP3, and PFP4, were obtained and structurally characterized. The results showed that PFP2, PFP3, and PFP4 were three structurally similar hetero-galacturonans with different molecular weights of 6.11 x 10(4), 4.37 x 10(4), and 3.48 x 10(5) g/mol, respectively. All three of these hetero-galacturonans are mainly composed of galacturonic acid, galactose, arabinose (75.69%, 80.39%, and 74.30%, respectively), and other monosaccharides including mannose, fucose, glucose, ribose, xylose, and glucuronic acid (24.31%, 19.61, and 25.70%, respectively), although differences in their backbone structure exist. Additionally, immunomodulatory assay indicated that the three hetero-galacturonans possess the ability to promote the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha, and interleukin-6 (IL-6) in RAW264.7 macrophages in a concentration-dependent manner (p < 0.05). Especially, PFP3 displayed a stronger enhancing effect than PFP2 and PFP4 at the minimum effective concentration. Therefore, the results suggested that the obtained three salt-eluted hetero-galacturonans, especially PFP3, could be utilized as immunomodulatory effectivity ingredients in nutritional/pharmaceutical industries.

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