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Characterization and evaluation of the pathogenicity of a natural recombinant transmissible gastroenteritis virus in China

文献类型： 外文期刊

作者： Guo, Rongli 1 ; Fan, Baochao 1 ; Chang, Xinjian 1 ; Zhou, Jinzhu 1 ; Zhao, Yongxiang 1 ; Shi, Danyi 1 ; Yu, Zhengyu 1 ; H 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing 210014, Jiangsu, Peoples R China

2.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225000, Jiangsu, Peoples R China

3.Yangzhou Univ, Jiangsu Key Lab Zoonoses, Yangzhou 225000, Jiangsu, Peoples R China

4.Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Minist Sci & Technol, Nanjing 210014, Peoples R China

5.Hebei Normal Univ Sci & Technol, Coll Anim Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China

6.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China

关键词： TGEV; Recombination; Phylogenetic; Pathogenicity

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2020 年 545 卷

页码：

收录情况： SCI

摘要： Porcine transmissible gastroenteritis virus (TGEV) is one of the major etiological agents of viral enteritis and fetal diarrhea in suckling piglets. In this study, a TGEV JS2012 strain was isolated from the feces of piglets in Jiangsu Province, China. The phylogenetic analysis showed that TGEV JS2012 was placed between the Purdue and the Miller clusters. Analysis of recombination confirmed that TGEV JS2012 is a natural recombinant strain between Miller M6 and Purdue 115. Similar to Miller M6, virulent Purdue and China strain TS, in S gene the JS2012 maintained genetic integrity and the characteristics of the TGEV virulent strains. In vivo, TGEV JS2012 caused 100% mortality in newborn piglets, indicating the strong pathogenicity of this isolate. These results reveal that the JS2012 is a novel natural recombinant TGEV with high virulence. Our findings provide valuable information about genetic diversity and infection mechanism of the coronavirus family.

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