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Chromatin-associated SUMOylation controls the transcriptional switch between plant development and heat stress responses

文献类型： 外文期刊

作者： Han, Danlu 1 ; Chen, Chen 2 ; Xia, Simin 1 ; Liu, Jun 4 ; Shu, Jie 2 ; Nguyen, Vi 2 ; Lai, Jianbin 1 ; Cui, Yuhai 2 ; Yang, Chengwei 1 ;

作者机构： 1.South China Normal Univ, Sch Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Peoples R China

2.Agr & Agri Food Canada, London Res & Dev Ctr, London, ON N5V 4T3, Canada

3.Western Univ, Dept Biol, London, ON N6A 5B7, Canada

4.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou, Peoples R China

关键词： chromatin; development; heat stress; plant cells; SUMOylation; transcription

期刊名称：PLANT COMMUNICATIONS （ 影响因子：8.625； 五年影响因子：8.625 ）

ISSN： 2590-3462

年卷期： 2021 年 2 卷 1 期

页码：

收录情况： SCI

摘要： The post-translational protein modification known as SUMOylation has conserved roles in the heat stress responses of various species. The functional connection between the global regulation of gene expression and chromatin-associated SUMOylation in plant cells is unknown. Here, we uncovered a genome-wide relationship between chromatin-associated SUMOylation and transcriptional switches in Arabidopsis thaliana grown at room temperature, exposed to heat stress, and exposed to heat stress followed by recovery. The small ubiquitin-like modifier (SUMO)-associated chromatin sites, characterized by whole-genome ChIP-seq, were generally associated with active chromatin markers. In response to heat stress, chromatin-associated SUMO signals increased at promoter-transcriptional start site regions and decreased in gene bodies. RNA-seq analysis supported the role of chromatin-associated SUMOylation in transcriptional activation during rapid responses to high temperature. Changes in SUMO signals on chromatin were associated with the upregulation of heat-responsive genes and the downregulation of growth-related genes. Disruption of the SUMO ligase gene SIZ1 abolished SUMO signals on chromatin and attenuated rapid transcriptional responses to heat stress. The SUMO signal peaks were enriched in DNA elements recognized by distinct groups of transcription factors under different temperature conditions. These observations provide evidence that chromatin-associated SUMOylation regulates the transcriptional switch between development and heat stress response in plant cells.

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