您好，欢迎访问北京市农林科学院 机构知识库！
北京市农林科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Influenza A virus receptors in the respiratory and intestinal tracts of pigeons

文献类型： 外文期刊

作者： Liu, Yuehuan 1 ; Han, Chunhua 1 ; Wang, Xiuqing 2 ; Lin, Jian 1 ; Ma, Ming 1 ; Shu, Yuelong 3 ; Zhou, Jiao 1 ; Yang, Hanc 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim & Husb Med, Beijing 100089, Peoples R China

2.S Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA

3.Chinese Ctr Dis Control & Prevent, Chinese Natl Influenza Ctr, Beijing 100050, Peoples R China

4.China Agr Univ, Beijing 100094, Peoples R China

5.Zhejiang Acad Med Sci, Inst Biotechnol, Hangzhou 310013, Zhejiang, Peoples R China

6.Beijing Municipal Husb & Vet Gen Stn, Beijing 100107, Peoples R China

7.Beijing Municipal Husb & Vet Ge

关键词： Biochemistry and Molecular Biophysics;Infection;Digestive System: Ingestion and Assimilation;Respiratory System: Respiration;Veterinary Medicine: Medical Sciences

期刊名称：AVIAN PATHOLOGY （ 影响因子：3.378； 五年影响因子：3.237 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： To understand the basis of the resistance of pigeons to Asian lineage highly pathogenic avian influenza virus (HPAIV) subtype H5N1, we examined the presence of influenza virus receptors, sialic acids linked to galactose by an alpha-2,3 linkage (SA alpha 2,3Gal) or by an alpha-2,6 linkage (SA alpha 2,6Gal), in respiratory and intestinal tracts of pigeons and compared the distributions of N-acetylneuraminic and N-glycolylneuraminic acids in the trachea and intestines of pigeons and chickens. Results suggested that the epithelial surfaces of the larynx, trachea, bronchus, and bronchiole of pigeons contained abundant SA alpha 2,6Gal with little or no SA alpha 2,3Gal. In contrast, the epithelial surfaces of the pharynx, trachea, bronchus, and bronchiole of chickens contained mainly SA alpha 2,3Gal, a well-recognized receptor for avian influenza viruses including H5N1 HPAIV. A similar distribution pattern of N-acetylneuraminic and N-glycolylneuraminic acids in the trachea and intestines of pigeons and chickens was observed. Overall, the results suggest that SA alpha 2,6Gal is the major receptor in the pigeon airway, which may partly contribute to the resistance of pigeons to Asian lineage HPAIV subtype H5N1.

  • 相关文献

[1]Protection of chickens, with or without maternal antibodies, against IBDV infection by a recombinant IBDV-VP2 protein. Zhang, Peijun,Li, Yongqing,Zhou, Xuemei,Xiong, Jinmao,She, Ruiping,Wang, Decheng.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：北京市农林科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台