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Metagenomic analysis for exploring the potential of Lactobacillus yoelii FYL1 to mitigate bacterial diarrhea and changes in the gut microbiota of juvenile yaks

文献类型： 外文期刊

作者： Zhang, Jingbo 1 ; Shi, Bin 1 ; Lu, Sijia 3 ; Wang, Shuo 1 ; Ren, Xiaoli 1 ; Liu, Ruidong 1 ; Dong, Hailong 1 ; Li, Kun 3 ; Fouad, Dalia 4 ; Ataya, Farid Shokry 5 ; Mansoor, Muhammad Khalid 6 ; Qamar, Hammad 7 ; Wu, Qingxia 1 ;

作者机构： 1.Tibet Agr & Anim Husb Univ, Linzhi 860000, Xizang, Peoples R China

2.Tibet Autonomous Reg Acad Agr & Anim Sci, Inst Anim Husb & Vet Med, Lhasa 850009, Peoples R China

3.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Peoples R China

4.King Saud Univ, Coll Sci, Dept Zool, POB 22452, Riyadh 11495, Saudi Arabia

5.King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia

6.Islamia Univ Bahawalpur, Fac Vet & Anim Sci, Dept Microbiol, Bahawalpur 63100, Pakistan

7.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China

关键词： Lactobacillus; Yak; Diarrhea; Intestinal microbiota; Metagenomics

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0882-4010

年卷期： 2024 年 186 卷

页码：

收录情况： SCI

摘要： Diarrhea in calves is a common disease that results in poor nutrient absorption, poor growth and early death which leads to productivity and economic losses. Therefore, it is important to explore the methods to reduce diarrhea in yak's calves. Efficacy of lactic acid bacteria (LAB) for improvement of bacterial diarrhea is well recognized. For this purpose, two different doses (107 CFU, 1011 CFU) of Lactobacillus yoelii FYL1 isolated from yaks were fed to juvenile yaks exposed to E. coli O78. After a trial period of ten days fresh feces and intestinal contents of the experimental yaks were collected and metagenomics sequencing was performed. It was found that feeding a high dose of Lactobacillus yoelii FYL1 decreased abundance of phylum Firmicutes in the E. coli O78 infected group whereas, it was high in animals fed low dose of Lactobacillu yoelii FYL1. Results also revealed that counts of bacteria from the family Oscillospiraceae, genus Synergistes and Megasphaera were higher in control group whereas, order Bifidobacteriales and family Bifidobacteriaceae were higher in infected group. It was observed that bacterial counts for Pseudoruminococcus were significantly (P < 0.05) higher in animals of group that were given high dose of Lactobacillus yoelii FYL1 (HLAB). Compared to infected group multiple beneficial bacterial genera such as Deinococus and Clostridium were found higher in the animals that were given a low dose of Lactobacillus yoelii FYL1 (LLAB). The abundance of pathogenic bacterial genera that included Parascardovia, Bacteroides and Methanobrevibacter was decreased (P < 0.05) in the lower dose treated group. The results of functional analysis revealed that animals of LLAB had a higher metabolism of terpenoids and polyketides compared to animals of infected group. Virus annotation also presented a significant inhibitory effect of LLAB on some viruses (P < 0.05). It was concluded that L. yoelii FYL1 had an improved effect on gut microbiota of young yaks infected with E. coli O78. This experiment contributes to establish the positive effects of LAB supplementation while treating diarrhea.

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