Aqueous extract of Sanghuangporus baumii induces autophagy to inhibit cervical carcinoma growth
文献类型： 外文期刊
作者： Wu, Di 1 ; Yuan, Xuemei 2 ; Zhou, Ruijie 2 ; Chen, Wanchao 1 ; Li, Wen 1 ; Li, Zhengpeng 1 ; Li, Xueyin 2 ; Zhu, Rui 3 ; Wang, Hualin 2 ; Yang, Yan 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South,Mi, Shanghai 201403, Peoples R China
2.Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan, Peoples R China
3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Integrated Chinese & Western Med, Wuhan, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）
ISSN： 2042-6496
年卷期： 2023 年 14 卷 5 期
页码：
收录情况： SCI
摘要： Sanghuangporus baumii, an edible fungus rich in heteropolysaccharides, has been found to have some anti-cervical cancer effects. In the current study, the effects of an aqueous extract of S. baumii on cervical cancer were investigated in a U14 cervical carcinoma cell implanted female Kunming mouse model. An aqueous extract of S. baumii (SHWE) was administered to tumor-bearing mice by gavage for 21 days. SHWE treatment significantly inhibited tumor growth by 67.4% at a dose of 400 mg per kg bodyweight. Transcriptomic results showed that the expression of key genes GABARAP, VMP1, VAMP8 and STX17 which are involved in the autophagy pathway was regulated after SHWE treatment, suggesting that SHWE may induce autophagy in tumors. The results were further confirmed by measuring the LC3II/LC3I ratio using western blotting. Moreover, some differentially expressed genes were involved in the insulin signaling pathway, implying that SHWE induced autophagy by disturbing glucose uptake and utilization in tumors. The analysis of the gut microbiota indicated that SHWE treatment stimulated the proliferation of Akkermansia, a well-known probiotic that presented benefits in metabolic regulation and cancer therapy. In conclusion, SHWE administration modified the gut microbiota, disturbed the glucose metabolism and induced autophagy in tumors, and then inhibited the development of cervical carcinoma in vivo.
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