Nanoliposome based strategy for enhancing bioavailability and antitumor activity of polyphenol from Sanghuangporus vaninii
文献类型： 外文期刊
作者： Liu, Peng 1 ; Wang, Yuyang 1 ; Zhang, Zhong 1 ; Wu, Di 1 ; Chen, Wanchao 1 ; Li, Wen 1 ; Liu, Junbo 4 ; Wang, Weike 4 ; Yang, Yan 1 ;
作者机构： 1.Inst Edible Fungi, Shanghai Acad Agr Sci, Key Lab Edible Fungi Resources & Utilizat South, Minist Agr, Shanghai 201403, Peoples R China
2.Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China
3.Shanghai Guosen Biotechnol Co Ltd, Shanghai 201400, Peoples R China
4.Hangzhou Acad Agr Sci, Hangzhou 310024, Peoples R China
关键词： Sanghuangporus vaninii; Nanoliposome; Liver tumor; Polyphenol; Bioavailability
期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）
ISSN： 2212-4292
年卷期： 2025 年 63 卷
页码：
收录情况： SCI
摘要： Sanghuangporus vaninii as a valuable edible fungus represents a high source of polyphenols with multidimensional bioactivities. However, the conundrum of the oral bioavailability of polyphenols limits its biological activity. Therefore, a strategy of nanoliposome was employed to enhance oral bioavailability of polyphenols from S. vaninii. In this study, a polyphenol component (PV5) with excellent inhibition of HepG2 cells was isolated and purified from S. vaninii. For enhancing bioavailability and bioactivity of PV5, nanoliposomes-loaded with PV5 (PV5-NPs) with an average particle size of (110.17 +/- 2.01) nm were prepared, and improved the oral bioavailability of PV5 in vivo. Additionally, PV5-NPs synergistically enhanced the antitumor activity in the H22 tumor bearing mice, reflecting in reducing tumor size and increasing levels of pro-apoptotic factors. The mechanism of PV5-NPs against liver tumor might be attributed to the blocking MEK/ERK pathway. The bioactive agents of PV5 such as Phellibaumin A, Phelligridin_C and Hispidin played a key role in the antitumor activity. Consequently, this study indicated that nanoliposomes could be used as a potential strategy for elevating bioavailability and bioactivity of polyphenols from S. vaninii.
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