Anti-hyperuricemia effects of a polysaccharide-protein complex from Lentinula edodes mediated by gut-kidney axis
文献类型： 外文期刊
作者： Xiong, Xinyi 1 ; Liu, Peng 1 ; Liu, Liping 1 ; Feng, Jie 1 ; Zhang, Jingsong 1 ; Yan, Mengqiu 1 ; Liu, Yanfang 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Edible Fungal Resources & Utilizat South, Minist Agr & Rural Affairs, Shanghai, Peoples R China
2.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
3.Natl R&D Ctr Edible Fungi Proc, Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China
关键词： Hyperuricemia; Lentinula edodes; Polysaccharide-protein complex; Gut microbiota; Gut-kidney axis
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 293 卷
页码：
收录情况： SCI
摘要： In order to investigate the effects of Lentinula edodes (L. edodes) on hyperuricemia, a polysaccharide-protein complex (LEPP) was prepared and characterized, and the activity was also systematically studied. LEPP was mainly composed of proteins (18.55 %) and polysaccharides (36.98 %) with three polysaccharide fractions (molecular weights were 8.98 x 10(6), 7.34 x 10(7) and 1.15 x 10(7) g/mol). The experiment results showed that 250-1000 mg/kg/day LEPP could decrease the serum uric acid (UA) level from 281.62 to 109.42-138.12 mu mol/L (p < 0.001), and there were significant differences between high and low doses (p < 0.05). LEPP simultaneously improved renal function, relieved oxidative stress and inflammation in the kidney and regulated renal UA transporters (URAT1, GLUT9, OAT1 and ABCG2) of hyperuricemia rats. Furthermore, gut microbiota dysbiosis and intestinal barrier function disruption were modified by LEPP. Among them, LEPP could reverse the relative abundances of Parabacteroides, Lachnospiraceae, Colidextribacter, UCG-010, Monoglobus, Lactobacillus and Muribaculaceae, which were associated with regulating the UA level, renal function and the expression of renal UA transporters in hyperuricemia rats through correlation analysis. Conclusively, LEPP prevented the pathological process of hyperuricemia through regulating the gut-kidney axis, which provided its complementary role in existing anti-hyperuricemia treatment strategies.
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