Innovative submerged directed fermentation: Producing high molecular weight polysaccharides from Ganoderma lucidum
文献类型： 外文期刊
作者： Guo, Jia 1 ; Tang, Chenmin 1 ; Liu, Yanfang 1 ; Shi, Jia 1 ; Vunduk, Jovana 3 ; Tang, Chuanhong 1 ; Feng, Jie 1 ; Zhang, Jingsong 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, China Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South,Mi, 1000 Jinqi Rd, Shanghai 201403, Peoples R China
2.Univ Shanghai Sci & Technol, Shanghai Engn Res Ctr Food Microbiol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China
3.Inst Gen & Phys Chem, Studenski Trg 10-12, Belgrade 11158, Serbia
关键词： Ganoderma lucidum; Submerged fermentation; High molecular weight polysaccharide
期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）
ISSN： 0308-8146
年卷期： 2025 年 471 卷
页码：
收录情况： SCI
摘要： Polysaccharides from Ganoderma lucidum (GLPs) exhibit unique bioactivity, but traditional cultivation yields low quantities and unstable quality, limiting their research and application. This study highlights how submerged fermentation processes enable the directed acquisition of structurally defined high molecular weight (MW) bioactive intracellular polysaccharides (IPS). The results showed that inoculation amount and fermentation scales had a significant effect on the content of high MW IPS. In the fermentor, by lowering the initial glucose concentration combined with fed-batch fermentation, the high MW IPS content was improved. The monosaccharide composition indicated that the high MW IPS obtained from different fermentation scales exhibited stability. This polysaccharide, which is a (3-glucan with a (3-1,3-Glcp backbone and (3-1-Glcp attached at the O-6 position, demonstrated immunostimulatory effects in vitro. Overall, the consistent quality of GLPs during submerged fermentation underscores the feasibility of industrial-scale production, presenting a significant advancement over traditional cultivation methods and promising for biotechnological applications.
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