文献类型： 外文期刊

作者： Jiao, Fengyuan ¹ ; Zhao, Yu ² ; Zhou, Gengxu ¹ ; Meng, Chi ¹ ; Wang, Lingjie ¹ ; Wu, Shengping ¹ ; Li, Jixiang ¹ ; Cao, Liting ¹ ; Zhou, Bo ³ ; Luo, Yichen ¹ ; Jiao, Hanwei ¹ ;

作者机构： 1.Southwest Univ, Coll Vet Med, Chongqing 402460, Peoples R China

2.Guizhou Acad Agr Sci, Inst Anim Husb & Vet Med, Key Lab Crop Genit Resources & Germplasm Innovat K, Minist Agr & Rural Affairs, Guiyang 550005, Peoples R China

3.Chinese Acad Agr Sci, Vet Res Inst, Yujinxiang St 573, Changchun 130102, Peoples R China

关键词： HE; HEV; ORF3

期刊名称：MICROORGANISMS （ 影响因子：4.1； 五年影响因子：4.5 ）

ISSN：

年卷期： 2024 年 12 卷 7 期

页码：

收录情况： SCI

摘要： Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The pathogen, HEV, has three Open Reading Frames (ORFs) ORF1, ORF2, and ORF3, each of which has a different function. Most of the current research is focused on ORF1 and ORF2, while the research on ORF3 is still relatively small. To provide more ideas for the study of HEV pathogenesis and the prevention and treatment of HE, this paper reviews the effects of ORF3 on the ERK pathway, growth factors, immune response, and virus release.