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Anchoring red blood cell with tetrahedral DNA nanostructure: Electrochemical biosensor for the sensitive signage of circulating tumor DNA

文献类型： 外文期刊

作者： Zha, Xinyue 1 ; Qin, Weiwei 3 ; Chen, Jiadi 1 ; Chen, Mengting 1 ; Zhang, Qiyue 1 ; He, Kaiyu 2 ; Liu, Yingju 1 ; Liu, Weipeng 1 ;

作者机构： 1.South China Agr Univ, Coll Mat & Energy, Minist Educ, Key Lab Biobased Mat & Energy, Guangzhou 510642, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

3.China Jiliang Univ, Coll Life Sci, Zhejiang Prov Key Lab Biometrol & Inspect & Quara, Hangzhou 310018, Peoples R China

关键词： Tetrahedral DNA nanostructures; Electrochemical biosensor; Circulating tumor cells; ctDNA; Methylene blue

期刊名称：TALANTA （ 影响因子：6.1； 五年影响因子：5.4 ）

ISSN： 0039-9140

年卷期： 2023 年 251 卷

页码：

收录情况： SCI

摘要： Circulating tumor cells (CTCs), as a type of tumor, have attracted wide attention because of their characteristics of shedding from the primary tumor and spreading to other tissues and organs through peripheral blood. The circulating tumor DNA (ctDNA), the DNA released by CTCs and other tumor cells into the peripheral blood, was considered as a promising detection substance for clinical application. By utilizing the biocompatibility of red blood cells to realize the attachment of tetrahedral DNA (TDN), as well as the specific target recognition ability of TDN to enable efficient recognition of targets, a biocompatible electrochemical biosensor for effective and rapid detection of ctDNA was developed using methylene blue (MB) as the signal probe. The current signal and the logarithm of ctDNA concentration were linearly correlated in the range from 1 fM to 100 pM with the detection limit of 0.66 fM. With high specificity, the TDN-based biosensor can detect ctDNA efficiently in the real biological environment such as serum, which provided a potential opportunity for the early clinical diagnosis.

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