Prostaglandin Metabolome Profiles in Zebrafish (Danio rerio) Exposed to Acetochlor and Butachlor
文献类型： 外文期刊
作者： Wu, Shenggan 1 ; Zhou, Xinzong 2 ; Qin, Weiwei 2 ; An, Xuehua 1 ; Wang, Feidi 1 ; Lv, Lu 1 ; Tang, Tao 1 ; Liu, Xinju 1 ; He, Yueping 2 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
2.Huazhong Agr Univ, Coll Plant Sci & Technol, Hubei Insect Resources Utilizat & Sustainable Pest, Wuhan 430070, Peoples R China
关键词： prostaglandins; metabolites; isoprostanes; Danio rerio; UPLC-ESI-MS; MS-metabolomics
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）
ISSN：
年卷期： 2023 年 24 卷 4 期
页码：
收录情况： SCI
摘要： Prostaglandins (PGs) are critically important signaling molecules that play key roles in normal and pathophysiological processes. Many endocrine-disrupting chemicals have been found to suppress PG synthesis; however, studies about the effects of pesticides on PGs are limited. The effects of two known endocrine disrupting herbicides, acetochlor (AC) and butachlor (BC), on PG metabolites in zebrafish (Danio rerio) females and males were studied using widely targeted metabolomics analysis based on ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). In total, 40 PG metabolites were detected in 24 zebrafish samples, including female and male samples, with and without exposure to AC or BC at the sub-lethal concentration of 100 mu g/L for 96 h. Among them, 19 PGs significantly responded to AC or BC treatment, including 18 PGs that were upregulated. The enzyme-linked immunosorbent assay (ELISA) test in zebrafish showed BC could cause significant upregulation of an isoprostane metabolite, 5-iPF2a-VI, which is positively related to the elevated level of reactive oxygen species (ROS). The present study guides us to conduct a further study to determine whether PG metabolites, including isoprostanes, could be potential biomarkers for chloracetamide herbicides.
- 相关文献
作者其他论文 更多>>
-
Assessment of pesticide exposure to applicators during spraying in orchards with a stretcher-mounted sprayer
作者：Tao, Chuanjiang;Zhang, Liying;Tao, Lingmei;Liu, Ran;Zhang, Hongjun;Huang, Xiuzhu;Mei, Chenghan;Li, Shuang;Yan, Yizhou;She, Dongmei;An, Xuehua;Fu, Qiang;Pu, Entang;Huang, Xiuzhu
关键词：Pesticide application; Occupational exposure; Orchard spraying; Stretcher-mounted sprayer; Risk assessment model
-
Comprehensive multi-omics investigation of sub-chronic toxicity induced by Cadmium and Triazophos Co-exposure in hook snout carps ( Opsariichthys bidens )
作者：Wang, Yanhua;Xu, Zhenlan;Lv, Lu;Wang, Dou;Wang, Xinquan;Gu, Weijie;Jin, Yuanxiang
关键词：Metabolome; Microbiology; Cadmium; Triazophos; Hook snout carp
-
Toxic mechanisms of imazalil, azoxystrobin and their mixture to hook snout carp (Opsariichthys bidens)
作者：Lv, Lu;Deng, Meihua;Di, Shanshan;Chu, Tianfen;Wang, Yanhua;Jia, Fangzhao
关键词：Aquatic toxicology; Chemical mixture; Physiological changes; Synergistic toxicity
-
Current-use pesticides monitoring and ecological risk assessment in vegetable soils at the provincial scale
作者：Zuo, Wei;Zhao, Yang;Qi, Peipei;Zhang, Chunrong;Zhao, Xueping;Wu, Shenggan;An, Xuehua;Liu, Xinju;Cheng, Xi;Tang, Tao;Yu, Yijun
关键词：Soil; Pesticide residue; Spatial distribution; Vegetable type; Ecological risk assessment
-
Enzymatic and transcriptional level changes induced by the co-presence of lead and procymidone in hook snout carp (Opsariichthys bidens)
作者：Wu, Shenggan;Di, Shanshan;Lv, Lu;Wang, Dou;Wang, Xinquan;Wang, Yanhua
关键词：Combined effect; Aquatic toxicology; Toxic mechanism; Gene expression
-
Biochemical and molecular-level effects of co-exposure to chlorpyrifos and lambda-cyhalothrin on the earthworm (Eisenia fetida)
作者：Wang, Dou;Yang, Guiling;Xu, Zhenlan;Lv, Lu;Tang, Tao;Wang, Yanhua;Chen, Liping
关键词：Earthworm; Toxicological mechanism; Mixture effect; Enzymatic activity; Gene transcription
-
Combined effects of azoxystrobin and oxytetracycline on rhizosphere microbiota of Arabidopsis thaliana
作者：Zhu, Yuke;Ke, Mingjing;Yu, Zhitao;Lei, Chaotang;Liu, Meng;Yang, Yaohui;Lu, Tao;Qian, Haifeng;Zhou, Ning-Yi;Peijnenburg, W. J. G. M.;Peijnenburg, W. J. G. M.;Tang, Tao
关键词：Pesticide; Arabidopsis thaliana; Combined exposure; Rhizosphere soil; Antagonism
