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A missense mutation in ISPD contributes to maintain muscle fiber stability

文献类型： 外文期刊

作者： Guo, Lijin 1 ; Zhang, Siyu 1 ; Xu, Yibin 1 ; Huang, Yulin 1 ; Luo, Wei 4 ; Wen, Qi 1 ; Liu, Guanxuan 1 ; Huang, Weiling 1 ; Xu, Haiping 1 ; Chen, Biao 3 ; Nie, Qinghua 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou, Guangdong, Peoples R China

2.South China Agr Univ, Coll Anim Sci, Key Lab Chicken Genet Breeding & Reprod, Minist Agr, Guangzhou, Guangdong, Peoples R China

3.Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang, Jiangxi, Peoples R China

4.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Key Lab Anim Breeding & Nutr,Guangdong P, Guangzhou, Peoples R China

关键词： ISPD; missense mutation; myogenesis; atrophy antagonism; myofiber stability

期刊名称：POULTRY SCIENCE （ 影响因子：4.014； 五年影响因子：4.192 ）

ISSN： 0032-5791

年卷期： 2022 年 101 卷 11 期

页码：

收录情况： SCI

摘要： Background: Livestock and poultry skel-etal muscle development was regulated by a variety of genetic factors playing an essential role in this process. In our de novo sequencing, a missense mutation in ISPD exon 2 showed a selected signature for well-developed muscles. However, the relationship between this muta-tion and muscle phenotypes remains unclear.Results: Based on the genotype bias of this missense mutation in gamecock chickens, we compared the cross-section of muscle fibers among the individuals with dif-ferent genotypes with the results showing a genotype preference of this missense mutation in the chickens with hypertrophic muscle fibers. Comparing TT-and CC-genotype ISPD showed that TT-genotype was asso-ciated with heavier skeletal muscle and a better effect on myogenesis and myofiber stability. At cellular level, ISPD was identified to inhibit myoblast proliferation, differentiation and antagonize of muscular atrophy.Conclusion: It can be concluded that the missense muta-tion of Arg84Lys in ISPD was associated with well -developed muscles and demonstrated to improve chicken muscles' development.

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