Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis
文献类型： 外文期刊
作者： Si, Fusheng 1 ; Song, Shuai 2 ; Yu, Ruisong 1 ; Li, Zhen 1 ; Wei, Wenqiang 4 ; Wu, Chao 5 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai Key Lab Agr Genet & Breeding, Shanghai Engn Res Centerof Breeding Pig, Shanghai 201106, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Hlth, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Minist Agr Rural Affairs, Guangzhou 510640, Peoples R China
3.Key Lab Anim Dis Prevent Guangdong Prov, Guangzhou 510640, Peoples R China
4.Henan Univ, Sch Basic Med Sci, Dept Microbiol, Kaifeng 475004, Henan, Peoples R China
5.Washington Univ St Louis, Dept Pathol & Immunol, St Louis, MO 63110 USA
期刊名称：ISCIENCE （ 影响因子：5.8； 五年影响因子：5.8 ）
ISSN：
年卷期： 2023 年 26 卷 4 期
页码：
收录情况： SCI
摘要： Coronavirus porcine epidemic diarrhea virus (PEDV) is classified in the genus Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 protein. However, how ORF3 contributes to viral pathogenicity, adaptability, and replication is obscure. In this review, we summarize current knowledge and identify gaps in many aspects of ORF3 protein in PEDV, with emphasis on its unique biological features, including membrane topology, Golgi retention mechanism, potential intrinsic disordered property, functional motifs, protein glycosylation, and codon usage phenotypes related to genetic evolution and gene expression. In addition, we propose intriguing questions related to ORF3 protein that we hope to stimulate further studies and encourage collaboration among virologists worldwide to provide constructive knowledge about the unique characteristics and biological functions of ORF3 protein, by which their potential role in clarifying viral behavior and pathogenesis can be possible.
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