Inhibitory Effect and Mechanism of Trichoderma taxi and Its Metabolite on Trichophyton mentagrophyte
文献类型： 外文期刊
作者： Xiao, Chenwen 1 ; Li, Lin 2 ; Liu, Yan 1 ; Huang, Yee 1 ; Wang, Yanli 2 ; Wang, Jiaoyu 2 ; Bao, Guolian 1 ; Sun, Guochang 2 ; Lin, Fucheng 2 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, State Key Lab Managing Biot & Chem Treats Qual &, Hangzhou 310021, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Managing Biot & Chem Treats Qual &, Hangzhou 310021, Peoples R China
关键词： Trichophyton mentagrophytes; trichodermin; Trichoderma taxi; endophytic fungi; ABC gene
期刊名称：JOURNAL OF FUNGI （ 影响因子：5.724； 五年影响因子：6.413 ）
ISSN：
年卷期： 2022 年 8 卷 10 期
页码：
收录情况： SCI
摘要： Trichophyton mentagrophytes is an important zoonotic dermatophyte, which seriously harms the skin of humans and animals. Chemical drugs are generally used for the prevention and treatment of the disease caused by T. mentagrophytes. Discovering new compounds from natural products is an important approach for new drug development. Trichoderma includes a variety of fungal species used for biological control of phytopathogenic fungi. However, the antifungal effects of Trichoderma and their metabolites on zoonotic fungal pathogens are largely unknown. Here, the effect of trichodermin, a metabolite derived from the plant endophytic fungus Trichoderma taxi, on T. mentagrophytes was examined, and the underlying mechanism was explored. T. mentagrophytes growth was suppressed significantly by trichodermin and completely inhibited under 1000 mu g/mL trichodermin. The production and germination of T. mentagrophytes spores were remarkably reduced upon exposure to trichodermin, in comparison with control samples. Treatment of lesions caused by T. mentagrophytes on the rabbit skin with 1 mg/mL trichodermin prompted the healing process significantly; however, 20 mg/mL trichodermin was likely toxic to the skin. Under trichodermin treatment, the number of mitochondria in T. mentagrophytes increased significantly, while a few mitochondria-related genes decreased, indicating possible mitochondrial damage. In transcriptome analysis, the GO terms enriched by DEGs in the trichodermin-treated group included carbohydrate metabolic process, integral component of membrane, intrinsic component of membrane, and carbohydrate binding, while the enriched KEGG pathways comprised biosynthesis of secondary metabolites, glycolysis/gluconeogenesis, and carbon metabolism. By comparing the wild type and a gene deletion strain of T. mentagrophytes, we found that CDR1, an ABC transporter encoding gene, was involved in T. mentagrophytes sensitivity to trichodermin.
- 相关文献
作者其他论文 更多>>
-
The nitrogen supply capacity and application methods of straw-chemical mixed fertilizer in the sweet corn variety 'Zhetian 19'
作者：Hou, Junfeng;Chen, Bin;Zhang, Ping;Tan, Heping;Han, Hailiang;Bao, Fei;Zhao, Fucheng;Wang, Yanli
关键词：SCMF; Sweet corn; Yield; Chlorophyll content; Dry matter; Soil nutrient
-
Bacillus amyloliquefaciens strain Q1 inoculation enhances salt tolerance of barley seedlings by maintaining the photosynthetic capacity and intracellular Na+/K+ homeostasis
作者：Liu, Hongjiang;Amoanimaa-Dede, Hanna;Zhang, Yanli;Wu, Xiaojian;Deng, Fenglin;Qin, Yuan;Zeng, Fanrong;Qiu, Haiping;Wang, Yanli;Ouyang, Younan
关键词：
Bacillus amyloliquefaciens ; Soil salinization; Photosynthetic attributes; Ion homeostasis; Antioxidant capacity;Hordeum vulgare L. -
The endosomal-vacuolar transport system acts as a docking platform for the Pmk1 MAP kinase signaling pathway in Magnaporthe oryzae
作者：Wang, Qing;Huang, Zhicheng;Li, Yan;Li, Hui;Lin, Fu-Cheng;Lu, Jianping;Wang, Jing;Cai, Yingying;Wang, Jiaoyu;Lin, Fu-Cheng;Huang, Pengyun;Liu, Xiaohong;Lin, Fu-Cheng
关键词：appressorium; endosome; MAPK; Pmk1; rice blast fungus; signal; ubiquitination; vacuole
-
A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae
作者：Huang, Zhicheng;Wang, Qing;Li, Yan;Li, Hui;Lin, Fu-Cheng;Lu, Jianping;Huang, Pengyun;Liao, Jian;Liu, Xiaohong;Lin, Fu-Cheng;Wang, Jing;Cai, Yingying;Wang, Jiaoyu;Lin, Fu-Cheng
关键词：
-
Genomic epidemiology of antimicrobial resistance determinants in Chinese swine farm Escherichia coli isolates
作者：Hu, Zizhe;Huang, Yee;Cui, Xuemei;Shi, Tuanyuan;Ji, Quanan;Bao, Guolian;Liu, Yan;Wang, Xiangru
关键词：pig farms;
Escherichia coli ; antimicrobial resistance; epidemiology; whole genome sequencing; horizontal transfer of ARGs -
Integrated metabolome and transcriptome provide insights into meat quality differences between Fujian yellow and New Zealand white rabbits
作者：Zhang, Jing;Yang, Jingyi;Han, Xudong;Ren, Yuyao;Zhao, Bohao;Wu, Xinsheng;Chen, Yang;Liu, Yan
关键词：Fujian yellow rabbit; New Zealand white rabbit; Metabolome; Transcriptome; Rabbit meat
-
Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection
作者：Islam, Mohammad Shafiqul;Noman, Muhammad;Zhang, Zhen;Wang, Jing;Lu, Ziqi;Cai, Yingying;Wang, Yanli;Wang, Jiaoyu;Islam, Mohammad Shafiqul;Li, Bin;Islam, Mohammad Shafiqul;Li, Bin;Ahmed, Md Robel;Ahmed, Temoor;Ahmed, Temoor;Sarwar, Abul Khayer Mohammad Golam
关键词：fungal disease; nanotechnology; plant protection; plant-pathogen interactions; RNAi
