HapX-mediated H2B deub1 and SreA-mediated H2A.Z deposition coordinate in fungal iron resistance
文献类型： 外文期刊
作者： Sun, Kewei 1 ; Li, Yiqing 1 ; Gai, Yunpeng 1 ; Wang, Jingrui 1 ; Jian, Yunqing 1 ; Liu, Xin 3 ; Wu, Liang 4 ; Shim, Won-Bo 5 ; Lee, Yin-Won 6 ; Ma, Zhonghua 1 ; Haas, Hubertus 7 ; Yin, Yanni 1 ;
作者机构： 1.Zhejiang Univ, Inst Biotechnol, State Key Lab Rice Biol, Key Lab Mol Biol Crop Pathogens & Insects, Hangzhou, Peoples R China
2.Beijing Forestry Univ, Sch Grassland Sci, Beijing, Peoples R China
3.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Nanjing, Peoples R China
4.Zhejiang Univ, Inst Crop Sci, Hangzhou, Peoples R China
5.Texas A&M Univ, Dept Plant Pathol & Microbiol, College Stn, TX USA
6.Seoul Natl Univ, Dept Agr Biotechnol, Seoul, South Korea
7.Med Univ Innsbruck, Instiute Mol Biol, Bioctr, A-6020 Innsbruck, Austria
期刊名称：NUCLEIC ACIDS RESEARCH （ 影响因子：14.9； 五年影响因子：16.4 ）
ISSN： 0305-1048
年卷期： 2023 年 51 卷 19 期
页码：
收录情况： SCI
摘要： Plant pathogens are challenged by host-derived iron starvation or excess during infection, but the mechanism through which pathogens counteract iron stress is unclear. Here, we found that Fusarium graminearum encounters iron excess during the colonization of wheat heads. Deletion of heme activator protein X (FgHapX), siderophore transcription factor A (FgSreA) or both attenuated virulence. Further, we found that FgHapX activates iron storage under iron excess by promoting histone H2B deubiquitination (H2B deub1) at the promoter of the responsible gene. Meanwhile, FgSreA is shown to inhibit genes mediating iron acquisition during iron excess by facilitating the deposition of histone variant H2A.Z and histone 3 lysine 27 trimethylation (H3K27 me3) at the first nucleosome after the transcription start site. In addition, the monothiol glutaredoxin FgGrx4 is responsible for iron sensing and control of the transcriptional activity of FgHapX and FgSreA via modulation of their enrichment at target genes and recruitment of epigenetic regulators, respectively. Taken together, our findings elucidated the molecular mechanisms for adaptation to iron excess mediated by FgHapX and FgSreA during infection in F. graminearum and provide novel insights into regulation of iron homeostasis at the chromatin level in eukaryotes. Graphical Abstract
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