Autophagy mediated degradation of MITA/TBK1/IRF3 by a hnRNP family member attenuates interferon production in fish
文献类型： 外文期刊
作者： Zhang, Yanwei 1 ; Cen, Jing 1 ; Wu, Haixia 1 ; Gao, Wa 1 ; Jia, Zhiying 4 ; Adamek, Mikolaj 5 ; Zou, Jun 1 ;
作者机构： 1.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China
2.Shanghai Ocean Univ, Int Res Ctr Marine Biosci, Minist Sci & Technol, Shanghai 201306, Peoples R China
3.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China
4.CAFS, Heilongjiang River Fisheries Res Inst, Harbin 150070, Heilongjiang, Peoples R China
5.Univ Vet Med Hannover, Inst Parasitol, Fish Dis Res Unit, Hannover, Germany
6.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Laoshan Lab, Qingdao 266200, Peoples R China
关键词： HnRNP A/B; Virus; Interferon; Autophagy
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）
ISSN： 1050-4648
年卷期： 2024 年 149 卷
页码：
收录情况： SCI
摘要： HnRNP A/B belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and plays an important role in regulating viral protein translation and genome replication. Here, we found that overexpression of hnRNP A/B promoted spring viremia of carp virus (SVCV) and cyprinid herpesvirus 3 (CyHV3) replication. Further, hnRNP A/B was shown to act as a negative regulator of type I interferon (IFN) response. Mechanistically, hnRNP A/B interacted with MITA, TBK1 and IRF3 to initiate their degradation. In addition, hnRNP A/B bound to the kinase domain of TBK1, the C terminal domain of MITA and IAD domain of IRF3, and the RRM1 domain of hnRNP A/B bound to TBK1, RRM2 domain bound to IRF3 and MITA. Our study provides novel insights into the functions of hnRNP A/B in regulating host antiviral response.
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