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Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

文献类型： 外文期刊

作者： Huang, Yingyi 1 ; Liu, Xiang 1 ; Wang, Hong-Yan 1 ; Chen, Jian-Yang 3 ; Zhang, Xianghui 3 ; Li, Yubang 1 ; Lu, Yifang 3 ; Dong, Zhongdian 5 ; Liu, Kaiqiang 1 ; Wang, Zhongduo 5 ; Wang, Qian 1 ; Fan, Guangyi 3 ; Zou, Jun 8 ; Liu, Shanshan 6 ; Shao, Changwei 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Natl Key Lab Mariculture Biobreeding & Sustainable, Qingdao 266072, Shandong, Peoples R China

2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266072, Shandong, Peoples R China

3.BGI Res, Qingdao 266555, Shandong, Peoples R China

4.BGI Res, Qingdao Key Lab Marine Genom, Qingdao 266555, Shandong, Peoples R China

5.Guangdong Ocean Univ, Guangdong Higher Educ Inst, Fisheries Coll, Key Lab Aquaculture South China Sea Aquat Econ Ani, Zhanjiang 524088, Guangdong, Peoples R China

6.MGI Tech, Shenzhen 518083, Peoples R China

7.BGI Res, Shenzhen 518083, Peoples R China

8.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2024 年 146 卷

页码：

收录情况： SCI

摘要： Nonalcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease in the world. Immunity is the major contributing factor in NAFLD; however, the interaction of immune cells and hepatocytes in disease progression has not been fully elucidated. As a popular species for studying NAFLD, zebrafish, whose liver is a complex immune system mediated by immune cells and non -immune cells in maintaining immune tolerance and homeostasis. Understanding the cellular composition and immune environment of zebrafish liver is of great significance for its application in NAFLD. Here, we established a liver atlas that consists of 10 cell types using single -cell RNA sequencing (scRNA-seq). By examining the heterogeneity of hepatocytes and analyzing the expression of NAFLD-associated genes in the specific cluster, we provide a potential target cell model to study NAFLD. Additionally, our analysis identified two subtypes of distinct resident macrophages with inflammatory and non -inflammatory functions and characterized the successive stepwise development of T cell subclusters in the liver. Importantly, we uncovered the possible regulation of macrophages and T cells on target cells of fatty liver by analyzing the cellular interaction between hepatocytes and immune cells. Our data provide valuable information for an in-depth study of immune cells targeting hepatocytes to regulate the immune balance in NAFLD.

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