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Whole-genome epidemiology and characterisation of mcr-1-encoding Escherichia coli in aquatic bird farms from the Pearl River Delta, China, 2019-2020

文献类型： 外文期刊

作者： Pan, Yu 1 ; Zeng, Zhenling 2 ; Niu, Huijun 1 ; Huang, Lang 2 ; Hu, Jianxin 2 ; Li, Guihua 3 ; Li, Yafei 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Qual Stand & Monitoring Technol Agroprod, Guangzhou 510640, Peoples R China

2.South China Agr Univ, Coll Vet Med, Natl Risk Assessment Lab Antimicrobial Resistance, Guangdong Prov Key Lab Vet Pharmaceut Dev & Safet, Guangzhou, Peoples R China

3.Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China

关键词： Antimicrobial resistance; mcr-1; Escherichia coli; Aquatic bird farms; Whole-genome sequencing; Public health

期刊名称：INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS （ 影响因子：15.441； 五年影响因子：9.742 ）

ISSN： 0924-8579

年卷期： 2022 年 59 卷 1 期

页码：

收录情况： SCI

摘要： Due to their unique breeding pattern, aquatic bird farms are increasingly considered as hotspots in the development and spread of antimicrobial resistance. However, comprehensive studies addressing the whole-genomic features of colistin-resistant bacteria in aquatic bird farms are scarce. Over a 2-year period, we conducted surveillance to determine the whole-genome epidemiology and characterisation of mcr-1-positive Escherichia coli in aquatic bird farms in southeastern coastal China. A total of 100 mcr-1-producing isolates among 654 E. coli strains were recovered from 781 samples collected in 11 aquatic bird farms and 1 veterinary clinic in the Pearl River Delta area. Higher resistance phenotypes to 17 antibiotics were found in mcr-1-positive isolates compared with other isolates. Subsequently, 20 mcr-1-carrying isolates were sequenced to analyse the whole-genomic features. Molecular typing as well as antimicrobial resistance gene and virulence factor profiles of the isolates showed considerable diversity. Three types of genetic backbones of mcr-1 in the isolates were assembled and were identified in diverse broad-hostrange plasmids and bacterial species. Pangenome analyses revealed a large genetic pool composed of the isolates. Furthermore, phylogenetic trees both of the isolates in this study and a global data set were built, indicating the spread of the three mcr-1 backbones and the mcr-1-positive isolates among different habitats, farms and even countries. This study highlights that aquatic bird farms may act as an important reservoir for mcr-1-producing E. coli, from which colistin resistance may be spread to diverse habitats, different geographical locations and even across bacterial species. (C) 2021 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.

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