CircNFIC Balances Inflammation and Apoptosis by Sponging miR-30e-3p and Regulating DENND1B Expression
文献类型： 外文期刊
作者： Chen, Yangfeng 1 ; Wang, Zhijun 1 ; Chen, Xiaolan 5 ; Peng, Xi 4 ; Nie, Qinghua 1 ;
作者机构： 1.South China Agr Univ, Guangdong Lab Lingnan Modern Agr Sci & Technol, Guangzhou 510642, Peoples R China
2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China
3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Peoples R China
4.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Peoples R China
5.Chongqing Univ, Sch Life Sci, Chongqing 401331, Peoples R China
关键词： inflammation; apoptosis; circular RNA;
miR-30e-3p/DENND1B axis
; Lipopolysaccharide期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）
ISSN：
年卷期： 2021 年 12 卷 11 期
页码：
收录情况： SCI
摘要： Disordered inflammation and apoptosis are closely related to diseases, and inflammation can also promote cell apoptosis, where growing evidence has shown that circular RNAs (circRNAs) play important roles. Lipopolysaccharide (LPS) is the main component of the cytoderm of gram-negative bacterium, which can cause inflammatory responses in macrophages. We constructed an inflammatory model by exposing chicken macrophage cell lines (also known as HD11) to LPS for in vitro experiments. In this study, we validated a novel circRNA-circNFIC-which was dramatically up-regulated in tissues infected by coccidia and cells exposed to LPS. Besides, circNFIC could significantly promote the expression levels of pro-inflammation factors, including (IL-1 beta, TNF alpha, and IFN gamma) and pro-apoptosis maker genes (caspase 3 and caspase 8) in HD11 exposed to LPS or not. In terms of mechanism, circNFIC exerted notable effects on DENND1B to regulate cell inflammation and apoptosis by sponging miR-30e-3p. The molecular functions played by miR-30e-3p and DENND1B have been explored, respectively. In addition, the effects of circNFIC knockdown suppressing the expression of pro-inflammatory and pro-apoptosis functions could be reversed by a miR-30e-3p inhibitor. On the whole, circNFIC promoted cell inflammation and apoptosis via the miR-30e-3p/DENND1B axis.
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