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Generation of E3-deleted canine adenovirus type 2 expressing the Gc glycoprotein of Seoul virus by gene insertion or deletion of related terminal region sequences

文献类型： 外文期刊

作者： Yuan, Zi-Guo 1 ; Luo, Sheng-Jun 3 ; Xu, Hui-Juan 4 ; Wang, Xiao-Hu 2 ; Li, Juan 1 ; Yuan, Li-Guo 1 ; He, Le-Tian 1 ; Zhan 1 ;

作者机构： 1.S China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China

2.Acad Mil Med Sci, Vet Inst, Lab Epidemiol, Changchun 130062, Peoples R China

3.Guangdong Acad Agr Sci, Inst Vet Med, Guangzhou 510640, Guangdong, Peoples R China

4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China

5.S China Agr Univ, Coll Agr, Guangzhou 510642, Guangdong, Peoples R China

期刊名称：JOURNAL OF GENERAL VIROLOGY （ 影响因子：3.891； 五年影响因子：3.719 ）

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收录情况： SCI

摘要： Seoul virus (SEOV) is one of the four hantaviruses known to cause haemorrhagic fever with renal syndrome. The medium genome segment encodes the Gn/Gc glycoproteins of SEOV, which form the major structural part of the virus envelope. Gc and/or Gn are the candidate antigens of hantavirus for induction of a highly immunogenic response for hantavirus vaccine. In this study, the immune response induced by a replication-competent recombinant canine adenovirus type 2 expressing the Gc protein of SEOV was evaluated in BALB/c mice. Sera from immunized mice contained neutralizing antibodies that could specifically recognize SEOV and neutralize its infectivity in vitro. Moreover, the recombinant virus induced complete protection against an intensive infectious challenge with ～1000 50% infective doses for SEOV strain CC-2. Protective-level neutralizing antibodies were maintained for at least 20 weeks. This recombinant virus is therefore a potential alternative to the inactivated vaccine.

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