文献类型： 外文期刊

作者： Wang, Ziye ¹ ; Yang, Zeyao ¹ ; Wang, Xinyu ¹ ; Xing, Lujuan ² ; Chen, Jiahui ³ ; Cao, Songmin ¹ ;

作者机构： 1.Ningxia Univ, Sch Food Sci & Engn, Yinchuan 750021, Peoples R China

2.Nanjing Agr Univ, Coll Food Sci & Technol, Key Lab Meat Proc & Qual Control, MOE, Nanjing 210095, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Agr Prod Proc, Nanjing 210014, Peoples R China

关键词： Chitosan-modified; Universal oral delivery system; PH response; Sustained release protection; Colloidal stability

期刊名称：FOOD AND BIOPRODUCTS PROCESSING （ 影响因子：3.4； 五年影响因子：4.2 ）

ISSN： 0960-3085

年卷期： 2025 年 152 卷

页码：

收录情况： SCI

摘要： This study successfully constructed an amphiphilic universal nanodelivery system (Trp-CS-PC) by modifying chitosan (CS) with hydrophobic L-Trp and dynamically self-assembling it with pectin (PC). This system achieved efficient and universal encapsulation of hydrophilic bovine collagen peptides (BCP) and hydrophobic curcumin (CUR) (encapsulation efficiency: BCP, 92.2 +/- 3.1 %; CUR, 73.4 +/- 4.5 %). Mechanistic studies indicate that the hydrophilic backbone in Trp-CS-PC fixes BCP through hydrogen bonding networks, while the hydrophobic microdomain stabilizes CUR through pi-pi stacking interactions. Trp-CS and PC formed a core-shell structure via pH-responsive ionic crosslinking, which maintained a tight network in the gastric environment, significantly reducing the release rates of BCP and CUR in gastric fluid (BCP: 18.23 +/- 1.05 %; CUR: 36.56 +/- 2.17 %). Trp modification significantly improved the solubility (5.95 +/- 0.38 mg/mL) and mucosal adhesion of CS, making this delivery system possess excellent storage stability (size variation <5 % within 28 days) and intestinal retention ability (cumulative release of BCP and CUR <59 % after gastrointestinal digestion). Furthermore, in vitro activity evaluation results showed that the biological activity retention of BCP and CUR delivered by Trp-CS-PC was significantly higher than that of the control group (P < 0.05). This study provides new ideas and strategies for the research and application of universal oral delivery systems for hydrophilic and hydrophobic bioactive substances.