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Mucosal and humoral responses of javelin goby, Synechogobius hasta, after immersion vaccination using killed Vibrio vulnificus bacterin

文献类型： 外文期刊

作者： Gao, Yingli 1 ; Qiang, Lu 1 ; Zhang, Liyuan 1 ; Tan, Ruiming 1 ; Wang, Xingqiang 1 ; Yu, Yongxiang 3 ;

作者机构： 1.Jiangsu Ocean Univ, Lab Pathol & Immunol Aquat Anim, Lianyungang 222005, Peoples R China

2.Jiangsu Ocean Univ, Jiangsu Key Lab Marine Biotechnol, Lianyungang 222005, Peoples R China

3.Chinese Acad Fishery Sci CAFS, Yellow Sea Fisheries Res Inst, Qingdao 266000, Peoples R China

关键词： Synechogobius hasta; Immersion vaccination; Antibody titers; Antigen uptake; Mucous cells

期刊名称：AQUACULTURE INTERNATIONAL （ 影响因子：2.953； 五年影响因子：2.94 ）

ISSN： 0967-6120

年卷期：

页码：

收录情况： SCI

摘要： Immersion vaccination is dependent on the response of fish mucosa-associated tissues. Herein, javelin goby Synechogobius hasta was immersed with Vibrio vulnificus bacterin to investigate mucosal and humoral immune responses post-vaccination. The results showed that the specific serum antibody titers gradually increased after vaccination and peaked at day 21, while the mucosal antibody titers in the gill, skin, and intestine showed a faster response, with the peak time at days 3, 5, and 7, respectively. For antigen uptake, a rapid and significant enhancement was detected in the mucosa-associated tissues (gill, skin, and intestine) compared with the blood, spleen, kidney, and liver (P < 0.05). Antigen uptake levels in the gills and skin were peaked at 12 h post-immersion and were significantly higher than other tissues (P < 0.05). The histological results showed that the mucous cell numbers in mucosa-associated tissues increased over time, peaked at day 3 post-immunization, and then decreased to the level of the control groups. Additionally, the mucin components in mucosa-associated tissues shifted from neutral mucopolysaccharide to acidic mucopolysaccharide. Integrations of antibody titers, antigen uptake in mucosa-associated tissues, mucous cell number changes, and mucin characteristic changes provided valuable information for research on mucosal immunity in fish. All present findings suggest a major advantage of immersion vaccines to elicit a high level of local immune response, making immersion vaccines an ideal mode of inoculation that induces protective immunity against a variety of pathogens.

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