Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness
文献类型： 外文期刊
作者： Luo, Ling-Yun 1 ; Wu, Hui 1 ; Zhao, Li-Ming 4 ; Zhang, Ya-Hui 1 ; Huang, Jia-Hui 1 ; Liu, Qiu-Yue 8 ; Wang, Hai-Tao 8 ; Mo, Dong-Xin 1 ; Eer, He-Hua 9 ; Zhang, Lian-Quan 10 ; Chen, Hai-Liang 11 ; Jia, Shan-Gang 12 ; Wang, Wei-Min 4 ; Li, Meng-Hua 1 ;
作者机构： 1.China Agr Univ, Frontiers Sci Ctr Mol Design Breeding MOE, Beijing, Peoples R China
2.China Agr Univ, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China
3.China Agr Univ, Coll Anim Sci & Technol, Beijing, Peoples R China
4.Lanzhou Univ, State Key Lab Herbage Improvement & Grassland Agro, Lanzhou, Peoples R China
5.Lanzhou Univ, Key Lab Grassland Livestock Ind Innovat, Minist Agr & Rural Affairs, Lanzhou, Peoples R China
6.Lanzhou Univ, Engn Res Ctr Grassland Ind, Minist Educ, Lanzhou, Peoples R China
7.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, Lanzhou, Peoples R China
8.Chinese Acad Sci, Inst Genet & Dev Biol, Innovat Acad Seed Design, Beijing, Peoples R China
9.Ningxia Acad Agr & Forestry Sci, Inst Anim Sci, Yinchuan, Peoples R China
10.Ningxia Shuomuyanchi Tan Sheep Breeding Co Ltd, Wuzhong, Peoples R China
11.Beijing Lvyeqingchuan Zoo Co Ltd, Beijing, Peoples R China
12.China Agr Univ, Coll Grassland Sci & Technol, Beijing, Peoples R China
期刊名称：NATURE GENETICS （ 影响因子：29.0； 五年影响因子：37.4 ）
ISSN： 1061-4036
年卷期： 2025 年 57 卷 1 期
页码：
收录情况： SCI
摘要： Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a few common failures and errors in genomic studies. Here, we report a 2.85-Gb gap-free telomere-to-telomere genome of a ram (T2T-sheep1.0), including all autosomes and the X and Y chromosomes. This genome adds 220.05 Mb of previously unresolved regions and 754 new genes to the most updated reference assembly ARS-UI_Ramb_v3.0; it contains four types of repeat units (SatI, SatII, SatIII and CenY) in centromeric regions. T2T-sheep1.0 has a base accuracy of more than 99.999%, corrects several structural errors in previous reference assemblies and improves structural variant detection in repetitive sequences. Alignment of whole-genome short-read sequences of global domestic and wild sheep against T2T-sheep1.0 identifies 2,664,979 new single-nucleotide polymorphisms in previously unresolved regions, which improves the population genetic analyses and detection of selective signals for domestication (for example, ABCC4) and wool fineness (for example, FOXQ1).
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