文献类型： 外文期刊

作者： Zhang, Xuhong ¹ ; Wang, Xiaoyu ¹ ; Zhu, Hong ¹ ; Zhang, Dongyan ¹ ; Chen, Jinbo ¹ ; Wen, Yingying ¹ ; Li, Yanqing ¹ ; Jin, Le ¹ ; Xie, Chen ¹ ; Guo, Dongyu ¹ ; Luo, Ting ⁴ ; Tong, Jianping ¹ ; Zhou, Yudong ¹ ; Shen, Ye ¹ ;

作者机构： 1.Zhejiang Univ, Affiliated Hosp 1, Dept Ophthalmol, Hangzhou, Zhejiang, Peoples R China

2.Zhejiang Univ, Ctr Brain Res & Brain Machine Integrat, Sch Brain Sci & Brain Med, Hangzhou, Zhejiang, Peoples R China

3.Shaoxing Cent Hosp, Dept Ophthalmol, Shaoxing 312030, Zhejiang, Peoples R China

4.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou, Peoples R China

关键词： Violet light; Visual development; MRNA sequencing; Synapses; Neurotransmitter transport

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2023 年 263 卷

页码：

收录情况： SCI

摘要： Nearly all modern life depends on artificial light; however, it does cause health problems. With certain restrictions of artificial light emitting technology, the influence of the light spectrum is inevitable. The most remarkable problem is its overload in the short wavelength component. Short wavelength artificial light has a wide range of influences from ocular development to mental problems. The visual neuronal pathway, as the primary light-sensing structure, may contain the fundamental mechanism of all light-induced abnormalities. However, how the artificial light spectrum shapes the visual neuronal pathway during development in mammals is poorly understood. We placed C57BL/6 mice in three different spectrum environments (full-spectrum white light: 400-750 nm; violet light: 400 & PLUSMN; 20 nm; green light: 510 & PLUSMN; 20 nm) beginning at eye opening, with a fixed light time of 7:00-19:00. During development, we assessed the ocular axial dimension, visual function and retinal neurons. After two weeks under short wavelength conditions, the ocular axial length (AL), anterior chamber depth (ACD) and length of lens thickness, real vitreous chamber depth and retinal thickness (LLVR) were shorter, visual acuity (VA) decreased, and retinal electrical activity was impaired. The density of S-cones in the dorsal and ventral retinas both decreased after one week under short wavelength conditions. In the ventral retina, it increased after three weeks. Retinal ganglion cell (RGC) density and axon thickness were not influenced; however, the axonal terminals in the lateral geniculate nucleus (LGN) were less clustered and sparse. Amacrine cells (ACs) were significantly more activated. Green light has few effects. The KEGG and GO enrichment analyses showed that many genes related to neural circuitry, synaptic formation and neurotransmitter function were differentially expressed in the short wavelength light group. In conclusion, exposure to short wavelength artificial light in the early stage of vision-dependent development in mice delayed the development of the visual pathway. The axon terminus structure and neurotransmitter function may be the major suffering.