beta-Ionone causes endocrine disruption, hyperpigmentation and hypoactivity in zebrafish early life stages
文献类型： 外文期刊
作者： Zhou, Weicheng 1 ; Wang, Yuming 3 ; Wang, Jinglong 1 ; Peng, Chengrong 1 ; Wang, Zhicong 1 ; Qin, Hongjie 2 ; Li, Genbao 3 ; Li, Dunhai 1 ;
作者机构： 1.Chinese Acad Sci, Key Lab Algal Biol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Guangdong Acad Agr Sci, Environm Hort Res Inst, Guangdong Key Lab Comprehens Innovat Utilizat Orn, Guangzhou 510640, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Xiangnan Univ, Sch Chem & Environm Sci, Chenzhou 423000, Peoples R China
关键词： Taste and odor; Toxicity; Melanin; Locomotion
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：10.753； 五年影响因子：10.237 ）
ISSN： 0048-9697
年卷期： 2022 年 834 卷
页码：
收录情况： SCI
摘要： In nature, the odorous substance beta-ionone has been widely detected in aquatic ecosystems. However, little is known about its ecotoxicological effects on freshwater vertebrates. In this study, we aimed to assess the acute toxicity of beta-ionone in zebrafish (Danio rerio) embryos from 2 to 120 h post fertilization (hpf) and investigate embryo development, locomotor behavior and pigmentation under different concentrations. The results showed that exposure to beta-ionone had an acute toxicity to early life stages of zebrafish and induced a decrease in hatching rate and an increase in the mortality and malformation rate. The median lethal concentration (LC50) of beta-ionone at 96 h was observed as 1321 mu g/L. In addition, beta-ionone not only affected the body length of zebrafish larvae but also regulated the transcription of genes and the levels of hormones involved in the growth hormone/insulin-like growth factor (GH/IGF) and the hypothalamic-pituitary-thyroid (HPT) axes. Moreover, exposure to beta-ionone induced significant decreases in locomotor activity and catecholamine neurotransmitters levels. Furthermore, beta-ionone stimulated pigmentation via regulation of tyrosinase activity and melanin-related gene expression. Overall, this research could provide new insights into the potential risk of odorants to aquatic organisms.
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