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Geosmin disrupts energy metabolism and locomotor behavior of zebrafish in early life stages

文献类型： 外文期刊

作者： Zhou, Weicheng 1 ; Wang, Yuming 4 ; Wang, Jinglong 1 ; Peng, Chengrong 1 ; Wang, Zhicong 1 ; Qin, Hongjie 3 ; Li, Genbao 4 ; Li, Dunhai 1 ;

作者机构： 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China

2.Xiangnan Univ, Sch Chem & Environm Sci, Hunan Prov Key Lab Xiangnan Rare Precious Met Cpds, Chenzhou 423000, Peoples R China

3.Guangdong Acad Agr Sci, Environm Hort Res Inst, Guangdong Key Lab Comprehens Innovat Utilizat Orna, Guangzhou 510640, Peoples R China

4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

6.Chinese Acad Sci, Inst Hydrobiol, 7 South Donghu Rd, Wuhan 430072, Peoples R China

关键词： Geosmin; Locomotion; Energy metabolism; Electron transport chain; Multi-omics

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 859 卷

页码：

收录情况： SCI

摘要： Geosmin has been commonly detected both in various aquatic environments and biota, but its exact toxicological mechanisms to organisms need further experimentation. In the present study, zebrafish embryos were exposed to geosmin at nominal concentrations of 50, 500 and 5000 ng/L for 120 h post-fertilization (hpf), followed by locomotor activity and biochemical parameter examination, and multi-omics investigation of the transcriptome and metabolome. The results showed that geosmin exposure significantly reduced the mitochondrial electron transport chain (ETC) complexes I-V, ATP content and mitochondrial respiration and suppressed the locomotor behavior of zebrafish larvae. Transcriptomics analysis revealed that the transcripts of genes involved in oxidative phosphorylation, glycolysis, and lipid metabolism were significantly affected, indicating that geosmin disrupts energy metabolism. Furthermore, meta-bolomics results showed that 3 classes of lipids, namely glycerophospholipids (GPs), sphingolipids (SLs) and fatty acyls (FAs) were significantly decreased after geosmin exposure. This study provides novel insight into the underlying mech-anisms of geosmin-induced energy metabolism and highlights the need for concern about geosmin exposure.

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