文献类型： 外文期刊

作者： Zhu, Rui ¹ ; Wu, Xue-Qin ¹ ; Zhao, Xue-Yuan ¹ ; Qu, Zi-Hui ⁴ ; Quan, Ya-Nan ⁵ ; Lu, Ming-Hui ¹ ; Liu, Zong-Yu ¹ ; Wu, Li-Fang ¹ ;

作者机构： 1.Jilin Agr Univ, Coll Anim Sci & Technol, Changchun 130118, Peoples R China

2.Jilin Agr Univ, Key Lab Anim Prod Prod Qual & Secur, Minist Educ, Changchun 130118, Peoples R China

3.Jilin Agr Univ, Jilin Prov Key Lab Anim Nutr & Feed Sci, Changchun 130118, Peoples R China

4.Jilin Acad Agr Sci, Inst Anim Nutr & Feed, Jilin 130119, Peoples R China

5.Jingyuetan Reservoir Management Off, Changchun 130118, Peoples R China

关键词： Taurine; Glycinin; Inflammation; Intestinal health; Rhynchocypris lagowskii Dybowski

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.622； 五年影响因子：4.799 ）

ISSN： 1050-4648

年卷期： 2022 年 129 卷

页码：

收录情况： SCI

摘要： The present study evaluated the protective effect and the regulatory mechanism of taurine on growth inhibition and intestinal damage induced by glycinin in juvenile Rhynchocypris lagowskii Dybowski. The control diets had no glycinin and taurine, the glycinin diets contained only 80 g/kg glycinin, and the glycinin + taurine diets contained 80 g/kg glycinin+10 g/kg taurine. Juvenile Rhynchocypris lagowskii Dybowski (4.65 +/- 0.03 g/tail) were respectively fed with these 3 diets for 8 weeks. The results showed that glycinin significantly decreased the final body weight, weight gain rate, specific growth rate, protein efficiency rate, feed efficiency rate and feeding rate of fish compared with the control group (P < 0.05). While taurine supplementation improved the growth performance and feed efficiency, but final body weight, weight gain rate, specific growth rate of the glycinin + taurine group were still significantly lower than the control group (P < 0.05). Compared with the glycinin group, taurine supplementation significantly increased whole-body and muscle crude protein content, and hepatopancreas and intestinal protease activities (P < 0.05). Distal intestinal villous dysplasia and mucosal damage, and increased intestinal mucosal permeability were observed in the glycinin group, while taurine supplementation alleviated these adverse effects. Usefully, taurine supplementation could also partially restore the impaired immune function and antioxidant capacity of fish fed glycinin diets. Compared with the glycinin group, taurine supplementation down-regulated pro-inflammatory cytokines TNF-alpha and IL-1 beta mRNA levels, and up-regulated anti-inflammatory cytokines IL-10 and TGF-beta mRNA levels. Furthermore, taurine partially reversed the reduction of antioxidant genes Nrf2?HO-1, CAT and GPx mRNA levels in distal intestine induced by glycinin. Concluded, 80 g/kg glycinin led to intestinal damage, digestive dysfunction and increased intestinal mucosal permeability in juvenile Rhynchocypris lagowskii Dybowski, and these adverse effects were ultimately manifested in growth inhibition. But taurine supplementation could partially mitigate the negative effects induced by glycinin.