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Unlocking the potential of N-acetylcysteine: Improving hepatopancreas inflammation, antioxidant capacity and health in common carp (Cyprinus carpio) via the MAPK/NF-κB/Nrf2 signalling pathway

文献类型： 外文期刊

作者： Zhu, Rui 1 ; Shang, Guo-Jun 1 ; Zhang, Bao-Yuan 1 ; Wang, Hao-Tong 1 ; Li, Liang 1 ; Wei, Xiao-fang 1 ; Li, Deng-Lai 1 ; Yang, Zhi-Yong 1 ; Qu, Zi-Hui 4 ; Quan, Ya-Nan 5 ; Liu, Si-Ying 1 ; Wang, Yin-Tao 1 ; Meng, Si-Tong 1 ; Wu, Li-Fang 1 ; Qin, Gui-Xin 1 ;

作者机构： 1.Jilin Agr Univ, Coll Anim Sci & Technol, Changchun 130118, Peoples R China

2.Jilin Agr Univ, Key Lab Anim Prod Prod Qual & Secur, Minist Educ, Changchun 130118, Peoples R China

3.Jilin Agr Univ, Jilin Prov Key Lab Anim Nutr & Feed Sci, Changchun 130118, Peoples R China

4.Jilin Acad Agr Sci, Changchun, Peoples R China

5.Jingyuetan Reservoir Management Off, Changchun 130118, Peoples R China

关键词： Inflammation; MAPK/NF-kappa B/Nrf2 signaling pathway; Hepatopancreas morphology; N-acetylcysteine; Cyprinus carpio

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2024 年 144 卷

页码：

收录情况： SCI

摘要： N-acetylcysteine (NAC) positively contributes to enhancing animal health, regulating inflammation and reducing stress by participating in the synthesis of cysteine, glutathione, and taurine in the body. The present study aims to investigate the effects of dietary different levels of NAC on the morphology, function and physiological state of hepatopancreas in juvenile common carp (Cyprinus carpio). 450 common carps were randomly divided into 5 groups: N1 (basal diet), N2 (1.5 g/kg NAC diet), N3 (3.0 g/kg NAC diet), N4 (4.5 g/kg NAC diet) and N5 (6.0 g/ kg NAC diet), and fed for 8 weeks. The results indicated that dietary 3.0-6.0 g/kg NAC reduced hepatopancreas lipid vacuoles and nuclear translocation, and inhibited apoptosis in common carp. Simultaneously, the activities of hepatopancreas alanine aminotransferase and aspartate aminotransferase progressively increased with rising dietary NAC levels. Dietary NAC enhanced the non-specific immune function of common carp, and exerted anti-inflammatory effects by inhibiting the MAPK/NF-kappa B signaling pathway. Additionally, dietary 3.0-6.0 g/kg NAC significantly improved the antioxidant capacity of common carp, which was associated with enhanced glutathione metabolism, clearance of ROS and the activation of Nrf2 signaling pathway. In summary, NAC has the potential to alleviate inflammation, mitigate oxidative stress and inhibit apoptosis via the MAPK/NF-kappa B/Nrf2 signaling pathway, thereby improving hepatopancreas function and health of common carp. The current findings provide a theoretical basis for promoting the application of NAC in aquaculture and ecological cultivation of aquatic animals.

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