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A Recombinant Chimera Vaccine Composed of LTB and Mycoplasma hyopneumoniae Antigens P97R1, mhp390 and P46 Elicits Cellular Immunologic Response in Mice

文献类型： 外文期刊

作者： Liu, Wei 1 ; Jiang, Peizhao 1 ; Song, Tao 2 ; Yang, Keli 1 ; Yuan, Fangyan 1 ; Gao, Ting 1 ; Liu, Zewen 1 ; Li, Chang 1 ; Guo, Rui 1 ; Xiao, Shaobo 3 ; Tian, Yongxiang 1 ; Zhou, Danna 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Key Lab Prevent & Control Agents Anim Bacteriosis, Hubei Prov Key Lab Anim Pathogen Microbiol,Minist, Wuhan 430070, Peoples R China

2.Hebei Normal Univ Sci & Technol, Coll Anim Sci & Technol, Hebei Key Lab Prevent Vet Med, Qinhuangdao 066004, Peoples R China

3.Huazhong Agr Univ, Coll Vet Med, Div Anim Infect Dis, State Key Lab Agr Microbiol,Key Lab Prevent Vet Me, Wuhan 430070, Peoples R China

关键词： Mycoplasma hyopneumoniae; multi-antigen; chimeric vaccine; immune responses

期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）

ISSN：

年卷期： 2023 年 11 卷 8 期

页码：

收录情况： SCI

摘要： Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (EP), leading to a mild and chronic pneumonia in swine. Relative control has been attained through active vaccination programs, but porcine enzootic pneumonia remains a significant economic challenge in the swine industry. Cellular immunity plays a key role in the prevention and control of porcine enzootic pneumonia. Therefore, the development of a more efficient vaccine that confers a strong immunity against M. hyopneumoniae is necessary. In this study, a multi-antigen chimera (L9m6) was constructed by combining the heat-labile enterotoxin B subunit (LTB) with three antigens of M. hyopneumoniae (P97R1, mhp390, and P46), and its immunogenic and antigenic properties were assessed in a murine model. In addition, we compared the effect of individual administration and multiple-fusion of these antigens. The chimeric multi-fusion vaccine induced significant cellular immune responses and high production of IgG and IgM antibodies against M. hyopneumoniae. Collec-tively, our data suggested that rL9m6 chimera exhibits potential as a viable vaccine candidate for the prevention and control of porcine enzootic pneumonia.

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