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Bee-safe peptidomimetic acaricides achieved by comparative genomics

文献类型： 外文期刊

作者： Jindal, Vikas 1 ; Li, Daqi 1 ; Rault, Leslie C. 4 ; Fatehi, Soheila 1 ; Singh, Rupinder 1 ; Mating, Moritz 1 ; Zou, Ye 5 ; Ng, Ho-Leung 5 ; Kaczmarek, Krzysztof 6 ; Zabrocki, Janusz 6 ; Gui, Shunhua 8 ; Smagghe, Guy 8 ; Anderson, Troy D. 4 ; Nachman, Ronald J. 6 ; Park, Yoonseong 1 ;

作者机构： 1.Kansas State Univ, Dept Entomol, 123 Waters Hall, Manhattan, KS 66506 USA

2.Punjab Agr Univ, Dept Entomol, Ludhiana 141004, Punjab, India

3.Shanxi Acad Agr Sci, Inst Plant Protect, 81 Longcheng St, Taiyuan 030031, Shanxi, Peoples R China

4.Univ Nebraska, Dept Entomol, 103 Entomol Hall, Lincoln, NE 68583 USA

5.Kansas State Univ, Dept Biochem & Mol Biophys, Manhattan, KS 66506 USA

6.USDA, Insect Neuropeptide Lab, Southern Plains Agr Res Ctr, 2881 F&B Rd, College Stn, TX 77845 USA

7.Lodz Univ Technol, Inst Organ Chem, PL-909024 Lodz, Poland

8.Univ Ghent, Dept Plants & Crops, Lab Agrozool, Coupure Links 653, B-9000 Ghent, Belgium

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.996； 五年影响因子：5.516 ）

ISSN： 2045-2322

年卷期： 2022 年 12 卷 1 期

页码：

收录情况： SCI

摘要： The devastating Varroa mite (Varroa destructor Anderson and Trueman) is an obligatory ectoparasite of the honey bee, contributing to significant colony losses in North America and throughout the world. The limited number of conventional acaricides to reduce Varroa mites and prevent disease in honey bee colonies is challenged with wide-spread resistance and low target-site selectivity. Here, we propose a biorational approach using comparative genomics for the development of honey bee-safe and selective acaricides targeting the Varroa mite-specific neuropeptidergic system regulated by proctolin, which is lacking in the honey bee. Proctolin is a highly conserved pentapeptide RYLPT (Arg-Tyr-Leu-Pro-Thr) known to act through a G protein-coupled receptor to elicit myotropic activity in arthropod species. A total of 33 different peptidomimetic and peptide variants were tested on the Varroa mite proctolin receptor. Ligand docking model and mutagenesis studies revealed the importance of the core aromatic residue Tyr2 in the proctolin ligand. Peptidomimetics were observed to have significant oral toxicity leading to the paralysis and death of Varroa mites, while there were no negative effects observed for honey bees. We have demonstrated that a taxon-specific physiological target identified by advanced genomics information offers an opportunity to develop Varroa mite-selective acaricides, hence, expedited translational processes.

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