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Different effects of continuous and pulsed Benzo[a]pyrene exposure on metabolism and antioxidant defense of large yellow croaker: Depend on exposure duration

文献类型： 外文期刊

作者： Zeng, Lin 1 ; Wang, Yong-Hong 1 ; Song, Wei 2 ; Ai, Chun-Xiang 3 ; Liu, Zi-Ming 4 ; Yu, Min-Hui 3 ; Zou, Wei-Guang 1 ;

作者机构： 1.Bengbu Univ, Coll Food & Biol Engn, Bengbu 233030, Anhui, Peoples R China

2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

3.Xiamen Univ, Coll Ocean & Earth Sci, Xiamen 361005, Peoples R China

4.Lishui Univ, Coll Ecol, Lishui 323000, Peoples R China

5.Joint Lab Deep Blue Fishering Engn & Qingdao Natl, Qingdao 266000, Peoples R China

关键词： Time-averaged concentration; Exposure regime; Exposure duration; Larimichthys crocea

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2023 年 263 卷

页码：

收录情况： SCI

摘要： This study aims to compare differential effects of continuous and pulsed BaP exposures on metabolism and antioxidant defense in the liver of large yellow croaker. Fish were subjected to BaP for 4 days and 36 days in three exposure regimes with the same time-averaged concentration of BaP: 4 & mu;g/L BaP continuously, 8 & mu;g/L BaP for 24 h every other day or 16 & mu;g/L BaP for 24 h every 4 days. Our results showed that compared to pulsed BaP exposures, continuous BaP exposure reduced BaP metabolism (CYP1A, CYP3A and AHR transcriptional expressions, GSH content, GSH/GSSG ratio, EROD and GST activities) and antioxidant defense (T-SOD activity) on day 4, resulting to the increases in MDA and PC contents, indicating that continuous BaP exposure induced more severe oxidative damage during the early stage of exposure. But continuous BaP exposure reduced MDA and PC contents by improving BaP metabolism and antioxidant defense during the late stage of exposure. CYP1B transcriptional expression and CAT activity were unsuitable biomarkers of both continuous and pulsed BaP exposures. In conclusion, our results demonstrated differential effects of continuous and pulsed exposures on BaP metabolism and antioxidant responses, which were depend on exposure duration.

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