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Advancement in the Antigenic Epitopes and Vaccine Adjuvants of African Swine Fever Virus

文献类型： 外文期刊

作者： Wu, Qiong 1 ; Li, Chang 1 ; Zhu, Bo 1 ; Zhu, Jiajia 1 ; Yang, Keli 1 ; Liu, Zewen 1 ; Liu, Wei 1 ; Gao, Ting 1 ; Yuan, Fangyan 1 ; Guo, Rui 1 ; Tian, Yongxiang 1 ; Zhou, Danna 1 ;

作者机构： 1.Inst Anim Husb & Vet, Hubei Acad Agr Sci, Key Lab Prevent & Control Agents Anim Bacteriosis, Hubei Prov Key Lab Anim Pathogen Microbiol,Minist, Wuhan 430064, Peoples R China

关键词： African swine fever virus; antigenic epitope; T-cell epitope; B-cell epitope; Vaccine adjuvants

期刊名称：PATHOGENS （ 影响因子：3.3； 五年影响因子：3.6 ）

ISSN：

年卷期： 2024 年 13 卷 8 期

页码：

收录情况： SCI

摘要： African swine fever virus (ASFV), a highly virulent double-stranded DNA virus, poses a significant threat to global pig farming, with mortality rates in domestic pigs reaching up to 100%. Originating in Kenya in 1921, ASFV has since proliferated to Western Europe, Latin America, Eastern Europe, and most recently China in 2018, resulting in substantial global agricultural losses. Antigenic epitopes, recognized by the immune system's T cells and B cells, are pivotal in antiviral immune responses. The identification and characterization of these antigenic epitopes can offer invaluable insights into the immune response against ASFV and aid in the development of innovative immunotherapeutic strategies. Vaccine adjuvants, substances that amplify the body's specific immune response to antigens, also play a crucial role. This review provides an overview of the progress in studying T/B-cell epitopes in ASFV proteins and ASFV vaccine adjuvants, highlighting their role in the immune response and potential use in new vaccine development.

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