Structural characterization of polysaccharide from Centipeda minima and its hypoglycemic activity through alleviating insulin resistance of hepatic HepG2 cells
文献类型： 外文期刊
作者： Chen, Juncheng 1 ; Li, Lin 1 ; Zhang, Xia 1 ; Wan, Liting 1 ; Zheng, Qingsong 1 ; Xu, Dan 1 ; Li, Yuting 3 ; Liang, Yi 4 ; C 1 ;
作者机构： 1.South China Univ Technol, Engn Res Ctr Starch & Plant Prot Deep Proc, Sch Food Sci & Engn,Minist Educ, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China
2.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangdong Key Lab Agr Prod Proc, Minist Agr & Rural Affairs,Key Lab Funct Foods, Guangzhou 510610, Peoples R China
3.Dongguan Univ Technol, Sch Chem Engn & Energy Technol, Dongguan 523808, Peoples R China
4.Guangdong Chongqing Font Biochem Sci & Tech Co, Maoming 525427, Peoples R China
5.Jiangmen Food Inspect Inst, Jiangmen 529000, Peoples R China
关键词： Polysaccharide; Characterization; Hypoglycemic activity; Insulin-resistance HepG2 cells
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.908 ）
ISSN： 1756-4646
年卷期： 2021 年 82 卷
页码：
收录情况： SCI
摘要： A novel polysaccharide (CMP-2B) was purified from Centipeda minima by anion-exchange and gel-permeation chromatography. Structural characterization revealed that CMP-2B was a homogeneous heteropolysaccharide with an average molecular weight of 113.193 KDa. CMP-2B was made up of mannose, galacturonic acid, galactose and arabinose with a molar ratio of 0.27:0.12:0.42:0.17. The backbone chain of CMP-2B consisted of 3,6)-alpha-D-Manp-(1 and 4,6)-beta-D-Galp-(1, and the branches were comprised of 4)-alpha-D-GalpA-(1, 6)-beta-D-Galp-(1, T alpha-L-Araf-(1 and 3)-alpha-L-Araf -(1. Besides, the results of antioxidant assays revealed that CMP-2B possessed signifcant free radical scavenging ability. Moreover, the results of hypoglycemic assays showed that CMP-2B displayed alpha-glucosidase inhibitory activities, and could significantly improve glucose consumption, glycogen synthesis and the activity of pyruvate kinase of insulin-resistance HepG2 cells. Overall, these results suggested that CMP-2B could be a new source for functional foods.
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