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Transcriptomic and antiviral analyses of PoIFN-Delta5 against porcine enteric viruses in porcine intestinal epithelial cells

文献类型： 外文期刊

作者： Zhu, Xuejiao 1 ; Fan, Baochao 1 ; Song, Shiying 1 ; Gao, Jie 1 ; Zhou, Jinzhu 1 ; Zhao, Yongxiang 1 ; Guo, Weilu 1 ; Zhang, Xue 1 ; Qian, Jiali 1 ; Zhu, Mingjun 1 ; Li, Jizong 1 ; Li, Yunchuan 1 ; Guo, Rongli 1 ; Fan, Huiying 6 ; Dong, Hailong 7 ; Zhang, Xuehan 1 ; Li, Bin 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing 210014, Jiangsu, Peoples R China

2.Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

3.Jiangsu Key Lab Food Qual, Safety State Key Lab Cultivat Base Minist Sci & Te, Nanjing, Peoples R China

4.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

5.Jiangsu Univ, Sch Life Sci, Zhenjiang 212013, Peoples R China

6.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China

7.Tibet Agr & Anim Husb Univ, Anim Sci Coll, Nyingchi 860000, Peoples R China

8.GuoTai Taizhou Ctr Technol Innovat Vet Biol, Taizhou 225300, Peoples R China

关键词： Transcriptomic analysis; Antiviral analysis; PoIFN-Delta5; Porcine enteric viruses

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）

ISSN： 0378-1135

年卷期： 2023 年 280 卷

页码：

收录情况： SCI

摘要： The interferon-delta family was first reported in domestic pigs and belongs to the type I interferon (IFN-I) family. The enteric viruses could cause diarrhea in newborn piglets with high morbidity and mortality. We researched the function of the porcine IFN-delta (PoIFN-8) family in the porcine intestinal epithelial cells (IPEC-J2) cells infected with porcine epidemic diarrhea virus (PEDV). Our study found that all PoIFN-8s shared a typical IFN-I signature and could be divided into five branches in the phylogenic tree. Different strains of PEDV could induce typical IFN transitorily, and the virulent strain AH2012/12 had the strongest induction of porcine IFN-8 and IFN-alpha (PoIFN-alpha) in the early stage of infection. In addition, it was found that PoIFN-85/6/9/11 and PoIFN-81/2 were highly expressed in the intestine. PoIFN-85 had a better antiviral effect on PEDV compared to PoIFN-81 due to its higher induction of ISGs. PoIFN-81 and PoIFN-85 also activated JAK-STAT and IRS signaling. For other enteric viruses, transmissible gastroenteritis virus (TGEV), porcine deltacoronavirus (PDCoV), and porcine rotavirus (PoRV), PoIFN-81 and PoIFN-85 both showed an excellent antiviral effect. Transcriptome analyses uncovered the differences in host responses to PoIFN-alpha and PoIFN-85 and revealed thousands of differentially expressed genes were mainly enriched in the inflammatory response, antigen processing and presentation, and other immune-related pathways. PoIFN-85 would be a potential antiviral drug, especially against porcine enteric viruses. These studies were the first to report the antiviral function against porcine enteric viruses and broaden the new acquaintances of this type of interferon though not novelly discovered.

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