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Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis

文献类型： 外文期刊

作者： Liu, Kun 1 ; Pei, Le 3 ; Shen, Yuan 1 ; Wu, Jindi 2 ; Qian, Yinghong 3 ; Zhang, Nan 1 ; Mao, Wei 2 ; Cao, Jinshan 2 ;

作者机构： 1.Inner Mongolia Med Univ, Sch Publ Hlth, Hohhot 010110, Peoples R China

2.Inner Mongolia Agr Univ, Coll Vet Med, Lab Vet Pharmacol, Hohhot 010018, Peoples R China

3.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010031, Peoples R China

关键词： Endometritis; S. aureus infection; Prostaglandin E2; Immunology

期刊名称：CYTOKINE （ 影响因子：3.8； 五年影响因子：3.7 ）

ISSN： 1043-4666

年卷期： 2024 年 175 卷

页码：

收录情况： SCI

摘要： S. aureus isolated from bacterial bovine endometritis is common in epidemiological reports, but is often ignored as a subclinical pathogenic microorganism. In a previous study, we showed that live S. aureus (LSA) and heat killed S. aureus (HK-SA) induce different inflammatory responses in bovine endometrial tissue, and possibly being associated with the accumulation of prostaglandin E2 (PGE2). Thus, in this study, we varied PGE2 concentrations using inhibitors or agonists in HK-SA-treated bovine endometrial tissues. The results demonstrated that PGE2 has a positive relationship with IL -6, TNF-alpha, and damage -associated molecular patterns (DAMPs; e.g., HMGB-1 and HABP-1) expression and tissues damage, and is regulated by the EP4-p38 MAPK pathway. We concluded that lipoproteins of S. aureus are associated with PGE2 generation. To further explore the relationship between LSA and PGE2 accumulation, we used the S. aureus strain SA113 lipoprotein knockout (SA113 Delta lpl) to infect bovine endometrial epithelial cells (BECs). LSA decreased PGE2, cAMP, EP4, IL -6, IL -8, cAMP secretion, and the MAPK and PKA signaling pathways when infected with SA113 Delta lpl, as compared with SA113-infected groups. Moreover, the adhesion and invasion of BECs were similarly downregulated when lipoproteins in S. aureus were knocked out. The results of this study show that PGE2 is involved in both HK-SA- and LSA-induced inflammatory responses in the bovine endometrium. We suggest that S. aureus infection is associated with bovine endometritis, and although HK-SA and LSA induce different inflammatory responses, the strategy of decreasing PGE2 accumulation is helpful in reducing the inflammation stage caused by S. aureus.

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