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Toxicokinetics and edible tissues-specific bioaccumulation of decabrominated diphenyl ethers (BDE-209) after exposure to the broilers

文献类型： 外文期刊

作者： Yang, Yi 1 ; Zhu, Xing 2 ; Rao, Qinxiong 1 ; Liu, Zehui 1 ; Yang, Junhua 1 ; Zhao, Zhihui 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Agrifood Stand & Testing, Shanghai 201403, Peoples R China

2.Guizhou Univ, Coll Anim Sci, Guiyang 550025, Guizhou, Peoples R China

关键词： Broiler; BDE-209; Pharmacokinetics; Accumulation kinetics; Distribution

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2022 年 248 卷

页码：

收录情况： SCI

摘要： Decabromodiphenyl ether (BDE-209), the primary constituent of a widely used flame retardant formulation, is often present in high levels in avian derived products and could be transferred to humans through consumption. The purpose of this study was to investigate the toxicokinetics and bioaccumulation patterns of BDE-209 in different tissues of broilers, which would benefit the evaluation of chicken product safety. Male broilers received a single oral administration of BDE-209 at 25 mg/kg.BW and then BDE-209 concentrations in the plasma, liver, leg muscle, breast muscle, and other tissues were measured using gas chromatography-electron capture detection (GC-ECD). The changes of BDE-209 concentrations in the plasma were fitted to a non-compartmental model for kinetic analysis. Peak values were observed at 24 h (t1/2 =168.28 h), and trace levels remained for four weeks. Additionally, Cmax in the liver was much higher than that in leg and breast muscles, and Tmax from the liver and muscle were 12 and 24 h, respectively. Residual BDE-209 was detected in all broiler tissues after 2 weeks, and concentrations were ranked as follows: fat > liver > thymus gland > heart > testis > thigh muscle > skin > lung > kidney > breast muscles > spleen (wet weight (ww)). Our results suggested that BDE-209 was widely distributed in different tissues after intestinal absorption, and preferentially accumulated in adipose and liver tissues. Observations of bioaccumulation and slow elimination in the liver and muscles provide critical insight into the toxicity of BDE-209 and risk assessment of edible tissues from broilers.

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